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- W2114887953 abstract "Glycogen localization in the myometrium and luminal epithelium of the rat uterus was studied by the periodic acid-leucofuchsin technique after ovariectomized rats had been treated with various regimens of 1.0 μg estradiol dipropionate and 50.0 μg clomiphene citrate. Three regimens were used: (a) one or three dosages of clomiphene, alone or in combination with one or three dosages of estradiol; (b) a single dosage of clomiphene before a single dosage of estradiol; (c) a single dosage of clomiphene after a single dosage of estradiol.The estrogenic effect of clomiphene on the myometrium was less than that of estradiol. Clomiphene suppressed myometrial glycogen accumulation induced by estradiol when administered with estradiol, six hours before the hormone, or as long as 24 hours after estradiol. The luminal epithelium responded differently to estradiol and clomiphene: the number of luminal epithelial cells containing glycogen strikingly increased after clomiphene treatment but not after estradiol treatment. A few scattered cells contained glycogen 24 hours after one dosage of the drug. Forty-eight hours after a single dosage or after three dosages of the drug administered one per day, every luminal epithelial cell contained glycogen. The effect of clomiphene on the luminal epithelium may be either a unique action of the drug or an abnormal response of the tissue, similar to that reported for high doses of estradiol. This effect of clomiphene on the luminal epithelium may possibly be a factor in the drug's ability to block blastocyst implantation in the rat." @default.
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- W2114887953 date "1971-04-01" @default.
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- W2114887953 title "Histochemical study of estrogenic and antiestrogenic effects of clomiphene citrate on glycogen synthesis by myometrium and luminal epithelium of rat uterus" @default.
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- W2114887953 doi "https://doi.org/10.1002/ar.1091690410" @default.
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