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- W2114888971 abstract "Improved understanding of the multilayer regulation of the human genome has led to a greater appreciation of environmental, nutritional, and epigenetic risk factors for human disease. Chromatin remodeling, histone tail modifications, and DNA methylation are dynamic epigenetic changes responsive to external stimuli. Careful interpretation can provide insights for actionable public health through collaboration between population and basic scientists and through integration of multiple data sources. We review key findings in environmental epigenetics both in human population studies and in animal models, and discuss the implications of these results for risk assessment and public health protection. To ultimately succeed in identifying epigenetic mechanisms leading to complex phenotypes and disease, researchers must integrate the various animal models, human clinical approaches, and human population approaches while paying attention to life-stage sensitivity, to generate effective prescriptions for human health evaluation and disease prevention." @default.
- W2114888971 created "2016-06-24" @default.
- W2114888971 creator A5008478119 @default.
- W2114888971 creator A5028712728 @default.
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- W2114888971 creator A5087457107 @default.
- W2114888971 date "2014-03-18" @default.
- W2114888971 modified "2023-10-01" @default.
- W2114888971 title "Epigenetics: Relevance and Implications for Public Health" @default.
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