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- W2114895669 abstract "Purpose: The aim of this study was to determine the energy (J/mm<SUP>3</SUP> tumor volume) and temperature required for a complete in-situ-ablation of experimental liver tumors. Methods: LITT was performed in VX-2 tumor-bearing rabbits using Nd-YAG-Laser (1064 nm) with a diffuser-tip applicator and a temperature feedback-system. The animals were randomized into 4 groups (n equals 20) that differed in the target temperature at the tumor border [45 degrees Celsius, 50 degrees Celsius, 55 degrees Celsius and 60 degrees Celsius]. Histological examination was done at 0 h, 24 h, 96 h and 14 days after LITT. Results: The pretreatment tumor volume of 2191 +/- 61 mm<SUP>3</SUP> was the same for all groups (p > 0.05). Energy and temperature required and the rate of incomplete tumor-ablation (recurrences) are listed below (* equals p < 0.05, Kruskal-Wallis test. Conclusions: (1) To achieve complete in-situ-ablation under the given conditions, it is necessary to apply laser-energy of 3 J/mm<SUP>3</SUP> tumor volume. (2) A minimum temperature of 60 degrees Celsius on the tumor border presumed an application of 10 minutes." @default.
- W2114895669 created "2016-06-24" @default.
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- W2114895669 date "2000-11-16" @default.
- W2114895669 modified "2023-09-23" @default.
- W2114895669 title "Laser-induced thermotherapy (LITT): energy and temperature determination for complete in-situ ablation of liver metastasis" @default.
- W2114895669 doi "https://doi.org/10.1117/12.409314" @default.
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