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- W2114901030 abstract "Hypertension (HTN) is quantitatively the major cardiovascular risk factor and responsible for ∼50% of cardiovascular morbidity and mortality. Blood pressure (BP) is also a classical complex genetic trait with heritability estimates of 30-50%. Although much is known about BP regulation, the intrinsic origin of essential HTN remains obscure although many environmental factors are known. Analyses of rare monogenic syndromes of HTN have focused attention on pathways that involve renal sodium handling, and steroid hormone metabolism including the mineralocorticoid receptor activity. The genetic basis of common essential HTN on the other hand is only just becoming accessible through high-throughput approaches. Unbiased genome-wide analyses of BP genomics have identified 43 genetic variants associated with systolic, diastolic BP, and HTN. It is highly likely based on current findings that there are hundreds of such loci with small effects on BP, opening a perspective on the genetic architecture of BP that was unknown before. It is our hope that the knowledge of these and further loci will lead to improved understanding of BP pathophysiology and to the identification of new targets for drug therapy." @default.
- W2114901030 created "2016-06-24" @default.
- W2114901030 creator A5064438341 @default.
- W2114901030 creator A5074262853 @default.
- W2114901030 date "2013-01-09" @default.
- W2114901030 modified "2023-10-11" @default.
- W2114901030 title "Genes for blood pressure: an opportunity to understand hypertension" @default.
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- W2114901030 cites W1963979553 @default.
- W2114901030 cites W1967020579 @default.
- W2114901030 cites W1969194165 @default.
- W2114901030 cites W1970516435 @default.
- W2114901030 cites W1974747095 @default.
- W2114901030 cites W1976635712 @default.
- W2114901030 cites W1978343601 @default.
- W2114901030 cites W1979069430 @default.
- W2114901030 cites W1980991473 @default.
- W2114901030 cites W1981054886 @default.
- W2114901030 cites W1989539292 @default.
- W2114901030 cites W1998590296 @default.
- W2114901030 cites W2000448320 @default.
- W2114901030 cites W2001629081 @default.
- W2114901030 cites W2012319132 @default.
- W2114901030 cites W2013524758 @default.
- W2114901030 cites W2019120014 @default.
- W2114901030 cites W2021723069 @default.
- W2114901030 cites W2031190713 @default.
- W2114901030 cites W2033210506 @default.
- W2114901030 cites W2034652601 @default.
- W2114901030 cites W2039945010 @default.
- W2114901030 cites W2041467022 @default.
- W2114901030 cites W2042103448 @default.
- W2114901030 cites W2044707173 @default.
- W2114901030 cites W2052724934 @default.
- W2114901030 cites W2053445878 @default.
- W2114901030 cites W2056367362 @default.
- W2114901030 cites W2061008984 @default.
- W2114901030 cites W2062856194 @default.
- W2114901030 cites W2066666285 @default.
- W2114901030 cites W2070117247 @default.
- W2114901030 cites W2073881942 @default.
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- W2114901030 cites W2080052553 @default.
- W2114901030 cites W2089400376 @default.
- W2114901030 cites W2094058624 @default.
- W2114901030 cites W2096318148 @default.
- W2114901030 cites W2101605059 @default.
- W2114901030 cites W2102622802 @default.
- W2114901030 cites W2103881469 @default.
- W2114901030 cites W2110085945 @default.
- W2114901030 cites W2110343195 @default.
- W2114901030 cites W2110808585 @default.
- W2114901030 cites W2111202666 @default.
- W2114901030 cites W2112222722 @default.
- W2114901030 cites W2115655044 @default.
- W2114901030 cites W2119369921 @default.
- W2114901030 cites W2120798274 @default.
- W2114901030 cites W2122164159 @default.
- W2114901030 cites W2124663880 @default.
- W2114901030 cites W2124873881 @default.
- W2114901030 cites W2129254992 @default.
- W2114901030 cites W2129991662 @default.
- W2114901030 cites W2130010931 @default.
- W2114901030 cites W2131447198 @default.
- W2114901030 cites W2134783591 @default.
- W2114901030 cites W2136078375 @default.
- W2114901030 cites W2140609764 @default.
- W2114901030 cites W2140733217 @default.
- W2114901030 cites W2140853270 @default.
- W2114901030 cites W2142766228 @default.
- W2114901030 cites W2145813488 @default.
- W2114901030 cites W2156510348 @default.
- W2114901030 cites W2160294128 @default.
- W2114901030 cites W2161935988 @default.
- W2114901030 cites W2161998322 @default.
- W2114901030 cites W2164265846 @default.
- W2114901030 cites W2166520734 @default.
- W2114901030 cites W2217809488 @default.
- W2114901030 cites W2327187337 @default.
- W2114901030 cites W3021842026 @default.
- W2114901030 cites W4240407864 @default.
- W2114901030 cites W4244918166 @default.
- W2114901030 cites W4246475368 @default.
- W2114901030 cites W4292172722 @default.
- W2114901030 cites W4361739011 @default.
- W2114901030 doi "https://doi.org/10.1093/eurheartj/ehs455" @default.
- W2114901030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3612776" @default.
- W2114901030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23303660" @default.
- W2114901030 hasPublicationYear "2013" @default.
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