FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114910318> ?p ?o ?g. }

• W2114910318 endingPage "3806" @default.
• W2114910318 startingPage "3800" @default.
• W2114910318 abstract "Ectodermal neural cortex (ENC) 1, a member of the kelch family of genes, is an actin-binding protein and plays a pivotal role in neuronal and adipocyte differentiation. The present study was designed to examine the gonadotropin regulation and action of ENC1 during the ovulatory process in immature rats. The levels of ENC1 mRNA and protein were stimulated by LH/human chorionic gonadotropin (hCG) within 3 h both in vivo and in vitro. In situ hybridization analysis revealed that ENC1 mRNA was localized not only in theca/interstitial cells but also in granulosa cells of preovulatory follicles but not of growing follicles in pregnant mare's serum gonadotropin/hCG-treated ovaries. LH-induced ENC1 expression was suppressed by a high dose of protein kinase C inhibitor RO 31-8220 (10 microM) but not by low doses of RO 31-8220 (0.1-1.0 microM), suggesting the involvement of atypical protein kinase C. ENC1 was detected in both nucleus and cytoplasm that was increased by LH/hCG treatment. Both biochemical and morphological analysis revealed that LH/hCG treatment increased actin polymerization within 3 h in granulosa cells. Interestingly, ENC1 physically associated with actin and treatment with cytochalasin D, an actin-depolymerizing agent, abolished this association. Confocal microscopy further demonstrated the colocalization of ENC1 with filamentous actin (F-actin). The present study demonstrates that LH/hCG stimulates ENC1 expression and increases F-actin formation in granulosa cells. The present study further shows the physical association of ENC1 and F-actin, implicating the role of ENC1 in cytoskeletal reorganization during the differentiation of granulosa cells." @default.
• W2114910318 created "2016-06-24" @default.
• W2114910318 creator A5010114810 @default.
• W2114910318 creator A5032602920 @default.
• W2114910318 creator A5036337216 @default.
• W2114910318 creator A5043280909 @default.
• W2114910318 creator A5051338980 @default.
• W2114910318 creator A5057801678 @default.
• W2114910318 creator A5062639778 @default.
• W2114910318 creator A5084219145 @default.
• W2114910318 date "2009-04-16" @default.
• W2114910318 modified "2023-09-30" @default.
• W2114910318 title "Expression of Ectodermal Neural Cortex 1 and Its Association with Actin during the Ovulatory Process in the Rat" @default.
• W2114910318 cites W1563205636 @default.
• W2114910318 cites W1966361056 @default.
• W2114910318 cites W1967032043 @default.
• W2114910318 cites W1977076736 @default.
• W2114910318 cites W1977795081 @default.
• W2114910318 cites W1992333152 @default.
• W2114910318 cites W1993243592 @default.
• W2114910318 cites W1995002689 @default.
• W2114910318 cites W1998479682 @default.
• W2114910318 cites W2006191070 @default.
• W2114910318 cites W2025515198 @default.
• W2114910318 cites W2031437469 @default.
• W2114910318 cites W2032166135 @default.
• W2114910318 cites W2037183604 @default.
• W2114910318 cites W2038269021 @default.
• W2114910318 cites W2041744828 @default.
• W2114910318 cites W2044138206 @default.
• W2114910318 cites W2044872545 @default.
• W2114910318 cites W2059823893 @default.
• W2114910318 cites W2063220206 @default.
• W2114910318 cites W2071768807 @default.
• W2114910318 cites W2072364269 @default.
• W2114910318 cites W2084999188 @default.
• W2114910318 cites W2085867052 @default.
• W2114910318 cites W2088664918 @default.
• W2114910318 cites W2090351541 @default.
• W2114910318 cites W2096791952 @default.
• W2114910318 cites W2097122796 @default.
• W2114910318 cites W2100156486 @default.
• W2114910318 cites W2101143531 @default.
• W2114910318 cites W2119104675 @default.
• W2114910318 cites W2122341014 @default.
• W2114910318 cites W2134696314 @default.
• W2114910318 cites W2159731164 @default.
• W2114910318 cites W2159843423 @default.
• W2114910318 cites W2168275924 @default.
• W2114910318 cites W300756903 @default.
• W2114910318 doi "https://doi.org/10.1210/en.2008-1587" @default.
• W2114910318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19372205" @default.
• W2114910318 hasPublicationYear "2009" @default.
• W2114910318 type Work @default.
• W2114910318 sameAs 2114910318 @default.
• W2114910318 citedByCount "6" @default.
• W2114910318 countsByYear W21149103182012 @default.
• W2114910318 countsByYear W21149103182016 @default.
• W2114910318 countsByYear W21149103182017 @default.
• W2114910318 countsByYear W21149103182022 @default.
• W2114910318 crossrefType "journal-article" @default.
• W2114910318 hasAuthorship W2114910318A5010114810 @default.
• W2114910318 hasAuthorship W2114910318A5032602920 @default.
• W2114910318 hasAuthorship W2114910318A5036337216 @default.
• W2114910318 hasAuthorship W2114910318A5043280909 @default.
• W2114910318 hasAuthorship W2114910318A5051338980 @default.
• W2114910318 hasAuthorship W2114910318A5057801678 @default.
• W2114910318 hasAuthorship W2114910318A5062639778 @default.
• W2114910318 hasAuthorship W2114910318A5084219145 @default.
• W2114910318 hasBestOaLocation W21149103181 @default.
• W2114910318 hasConcept C125705527 @default.
• W2114910318 hasConcept C126322002 @default.
• W2114910318 hasConcept C134018914 @default.
• W2114910318 hasConcept C142669718 @default.
• W2114910318 hasConcept C1491633281 @default.
• W2114910318 hasConcept C2775948956 @default.
• W2114910318 hasConcept C2776041460 @default.
• W2114910318 hasConcept C2777203538 @default.
• W2114910318 hasConcept C2778324911 @default.
• W2114910318 hasConcept C2778575703 @default.
• W2114910318 hasConcept C2778782382 @default.
• W2114910318 hasConcept C2778894405 @default.
• W2114910318 hasConcept C40209533 @default.
• W2114910318 hasConcept C55493867 @default.
• W2114910318 hasConcept C71315377 @default.
• W2114910318 hasConcept C71924100 @default.
• W2114910318 hasConcept C86803240 @default.
• W2114910318 hasConcept C95444343 @default.
• W2114910318 hasConceptScore W2114910318C125705527 @default.
• W2114910318 hasConceptScore W2114910318C126322002 @default.
• W2114910318 hasConceptScore W2114910318C134018914 @default.
• W2114910318 hasConceptScore W2114910318C142669718 @default.
• W2114910318 hasConceptScore W2114910318C1491633281 @default.
• W2114910318 hasConceptScore W2114910318C2775948956 @default.
• W2114910318 hasConceptScore W2114910318C2776041460 @default.
• W2114910318 hasConceptScore W2114910318C2777203538 @default.
• W2114910318 hasConceptScore W2114910318C2778324911 @default.
• W2114910318 hasConceptScore W2114910318C2778575703 @default.

• next