FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114920605> ?p ?o ?g. }

• W2114920605 endingPage "461" @default.
• W2114920605 startingPage "455" @default.
• W2114920605 abstract "Saxitoxin (STX) is the most potent representative among the paralytic shellfish poisoning (PSP) toxins, which are highly selective Na(+) channel-blocking alkaloids. This study investigated, in cultures of the cyanobacterium Cylindrospermopsis raciborskii T3, the effects of pH, salt, amiloride and lidocaine hydrochloride on total cellular levels of Na(+) and K(+) ions and STX accumulation. Both Na(+) levels and intracellular STX concentrations increased exponentially in response to rising alkalinity. NaCl inhibited cyanobacterial growth at a concentration of 10 mM. In comparison with osmotically stressed controls, however, NaCl promoted STX accumulation in a dose-dependent manner. A correlation was seen in the time-course of both total cellular Na(+) levels and intracellular STX for NaCl, amiloride and lidocaine exposure. The increase in cellular Na(+) induced by NaCl at 10 mM was coupled with a proportional accumulation of STX. The two Na(+) channel-blocking agents amiloride and lidocaine had opposing effects on both cellular Na(+) levels and STX accumulation. Amiloride at 1 mM reduced ion and toxin concentrations, while lidocaine at 1 micro M increased the total cellular Na(+) and STX levels. The effects of the channel-blockers were antagonistic and dependent on an alkaline pH. The results presented suggest that, in C. raciborskii T3, STX is responsive to cellular Na(+) levels. This may indicate that either STX metabolism or the toxin itself could be linked to the maintenance of cyanobacterial homeostasis. The results also enhance the understanding of STX production and the ecology of PSP toxin-producing cyanobacteria." @default.
• W2114920605 created "2016-06-24" @default.
• W2114920605 creator A5005091083 @default.
• W2114920605 creator A5012686763 @default.
• W2114920605 creator A5020265588 @default.
• W2114920605 creator A5029025188 @default.
• W2114920605 creator A5067181898 @default.
• W2114920605 date "2004-02-01" @default.
• W2114920605 modified "2023-10-15" @default.
• W2114920605 title "Interactions between intracellular Na+ levels and saxitoxin production in Cylindrospermopsis raciborskii T3" @default.
• W2114920605 cites W140762360 @default.
• W2114920605 cites W1500100760 @default.
• W2114920605 cites W1505385667 @default.
• W2114920605 cites W187009779 @default.
• W2114920605 cites W1964210708 @default.
• W2114920605 cites W1967662556 @default.
• W2114920605 cites W1969550626 @default.
• W2114920605 cites W1971215601 @default.
• W2114920605 cites W1971661496 @default.
• W2114920605 cites W1974885558 @default.
• W2114920605 cites W1980275980 @default.
• W2114920605 cites W1982576441 @default.
• W2114920605 cites W1983409302 @default.
• W2114920605 cites W1989197537 @default.
• W2114920605 cites W1992734373 @default.
• W2114920605 cites W1994120733 @default.
• W2114920605 cites W1994670311 @default.
• W2114920605 cites W1997433866 @default.
• W2114920605 cites W2005353465 @default.
• W2114920605 cites W2007636818 @default.
• W2114920605 cites W2012373677 @default.
• W2114920605 cites W2020009137 @default.
• W2114920605 cites W2024885111 @default.
• W2114920605 cites W2025360759 @default.
• W2114920605 cites W2028922575 @default.
• W2114920605 cites W2048164720 @default.
• W2114920605 cites W2056175113 @default.
• W2114920605 cites W2069154910 @default.
• W2114920605 cites W2073315516 @default.
• W2114920605 cites W2095559801 @default.
• W2114920605 cites W2113448091 @default.
• W2114920605 cites W2122570065 @default.
• W2114920605 cites W2130192863 @default.
• W2114920605 cites W2163877412 @default.
• W2114920605 cites W2395258656 @default.
• W2114920605 cites W4293247451 @default.
• W2114920605 doi "https://doi.org/10.1099/mic.0.26350-0" @default.
• W2114920605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14766924" @default.
• W2114920605 hasPublicationYear "2004" @default.
• W2114920605 type Work @default.
• W2114920605 sameAs 2114920605 @default.
• W2114920605 citedByCount "58" @default.
• W2114920605 countsByYear W21149206052012 @default.
• W2114920605 countsByYear W21149206052013 @default.
• W2114920605 countsByYear W21149206052014 @default.
• W2114920605 countsByYear W21149206052015 @default.
• W2114920605 countsByYear W21149206052016 @default.
• W2114920605 countsByYear W21149206052017 @default.
• W2114920605 countsByYear W21149206052018 @default.
• W2114920605 countsByYear W21149206052020 @default.
• W2114920605 countsByYear W21149206052021 @default.
• W2114920605 countsByYear W21149206052023 @default.
• W2114920605 crossrefType "journal-article" @default.
• W2114920605 hasAuthorship W2114920605A5005091083 @default.
• W2114920605 hasAuthorship W2114920605A5012686763 @default.
• W2114920605 hasAuthorship W2114920605A5020265588 @default.
• W2114920605 hasAuthorship W2114920605A5029025188 @default.
• W2114920605 hasAuthorship W2114920605A5067181898 @default.
• W2114920605 hasBestOaLocation W21149206051 @default.
• W2114920605 hasConcept C158278297 @default.
• W2114920605 hasConcept C178790620 @default.
• W2114920605 hasConcept C185592680 @default.
• W2114920605 hasConcept C2777367657 @default.
• W2114920605 hasConcept C2777559882 @default.
• W2114920605 hasConcept C2777646408 @default.
• W2114920605 hasConcept C2779149278 @default.
• W2114920605 hasConcept C2779608910 @default.
• W2114920605 hasConcept C2779669040 @default.
• W2114920605 hasConcept C2779792404 @default.
• W2114920605 hasConcept C2781028344 @default.
• W2114920605 hasConcept C2909208804 @default.
• W2114920605 hasConcept C505870484 @default.
• W2114920605 hasConcept C523546767 @default.
• W2114920605 hasConcept C537181965 @default.
• W2114920605 hasConcept C54355233 @default.
• W2114920605 hasConcept C55493867 @default.
• W2114920605 hasConcept C79879829 @default.
• W2114920605 hasConcept C86803240 @default.
• W2114920605 hasConceptScore W2114920605C158278297 @default.
• W2114920605 hasConceptScore W2114920605C178790620 @default.
• W2114920605 hasConceptScore W2114920605C185592680 @default.
• W2114920605 hasConceptScore W2114920605C2777367657 @default.
• W2114920605 hasConceptScore W2114920605C2777559882 @default.
• W2114920605 hasConceptScore W2114920605C2777646408 @default.
• W2114920605 hasConceptScore W2114920605C2779149278 @default.
• W2114920605 hasConceptScore W2114920605C2779608910 @default.
• W2114920605 hasConceptScore W2114920605C2779669040 @default.
• W2114920605 hasConceptScore W2114920605C2779792404 @default.

• next