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- W2114922466 abstract "BACKGROUND Resistant hepatitis B virus (HBV) strains develop in 30% of liver transplant recipients treated with lamivudine within 2 years from the time of transplantation. OBJECTIVE To assess safety and outcomes of tenofovir salvage therapy for patients with lamivudine resistance in a retrospective cohort of liver-transplanted patients. METHODS Medical records were retrospectively evaluated for patients who received tenofovir. Data collected included demographics, HBV serologic information prior to and during tenofovir therapy, drug-related complications, and creatinine clearance. Criteria for lamivudine resistance included elevation of liver chemistries along with reappearance of hepatitis B surface antigen, hepatitis Be antigen, and/or HBV DNA. RESULTS Sixteen patients showed resistance to lamivudine at 10–85 months (median 26) following liver transplantation. Tenofovir 300 mg/day orally was added in 8 patients 1–66 months after the development of viral lamivudine resistance and continued for 14–26 months (median 19.3). All 8 patients experienced HBV DNA viral suppression, with 7 currently nondetectable. No adverse events were reported, and creatinine clearance was not impaired. CONCLUSIONS Our results suggest that tenofovir safely and markedly decreases replication of lamivudine-resistant HBV variants after liver transplantation and is another potential option for the treatment of HBV lamivudine resistance." @default.
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- W2114922466 date "2004-10-26" @default.
- W2114922466 modified "2023-10-18" @default.
- W2114922466 title "Tenofovir Therapy for Lamivudine Resistance Following Liver Transplantation" @default.
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- W2114922466 doi "https://doi.org/10.1345/aph.1e280" @default.
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