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- W2114927679 abstract "Molecular dynamics (MD) simulations of N-terminal peptides from lactate dehydrogenase (LDH) with increasing length and individual secondary structure elements were used to study their stability in relation to folding. Ten simulations of 1–2 ns of different peptides in water starting from the coordinates of the crystal structure were performed. The stability of the peptides was compared qualitatively by analyzing the root mean square deviation (RMSD) from the crystal structure, radius of gyration, secondary and tertiary structure, and solvent accessible surface area. In agreement with earlier MD studies, relatively short (< 15 amino acids) peptides containing individual secondary structure elements were generally found to be unstable; the hydrophobic α1-helix of the nucleotide binding fold displayed a significantly higher stability, however. Our simulations further showed that the first βαβ supersecondary unit of the characteristic dinucleotide binding fold (Rossmann fold) of LDH is somewhat more stable than other units of similar length and that the α2-helix, which unfolds by itself, is stabilized by binding to this unit. This finding suggests that the first βαβ unit could function as an N-terminal folding nucleus, upon which the remainder of the polypeptide chain can be assembled. Indeed, simulations with longer units (βαβα and βαβαββ) showed that all structural elements of these units are rather stable. The outcome of our studies is in line with suggestions that folding of the N-terminal portion of LDH in vivo can be a cotranslational process that takes place during the ribosomal peptide synthesis." @default.
- W2114927679 created "2016-06-24" @default.
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- W2114927679 date "1996-04-01" @default.
- W2114927679 modified "2023-09-27" @default.
- W2114927679 title "Molecular dynamics simulations of N-terminal peptides from a nucleotide binding protein" @default.
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- W2114927679 doi "https://doi.org/10.1002/(sici)1097-0134(199604)24:4<450::aid-prot5>3.0.co;2-i" @default.
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