Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114944279> ?p ?o ?g. }
- W2114944279 endingPage "249" @default.
- W2114944279 startingPage "235" @default.
- W2114944279 abstract "The discovery, biological qualification and analytical validation of genomic biomarkers requires extensive collaborations between individuals with expertise in biology, statistics, bioinformatics, chemistry, clinical medicine, regulatory science and so on. For clinical utility, blood-borne biomarkers (e.g., mRNA and miRNA) of organ damage, drug toxicity and/or response would be preferred to those that are tissue based. Currently used biomarkers such as serum creatinine (indicating renal dysfunction) denote organ damage whether caused by disease, physical injury or drugs. Therefore, it is anticipated that studies of disease will discover biomarkers that can also be used to identify drug-induced injury and vice versa. This article describes transcriptomic blood-borne biomarkers that have been reported to be connected with disease and drug toxicity. Much more qualification and validation needs to be carried out before many of these biomarkers can prove useful. Discussed here are some of the lessons learned and roadblocks to success." @default.
- W2114944279 created "2016-06-24" @default.
- W2114944279 creator A5084672026 @default.
- W2114944279 date "2011-02-01" @default.
- W2114944279 modified "2023-09-26" @default.
- W2114944279 title "Transcriptional profiling to identify biomarkers of disease and drug response" @default.
- W2114944279 cites W1966214207 @default.
- W2114944279 cites W1968295800 @default.
- W2114944279 cites W1969350888 @default.
- W2114944279 cites W1970364433 @default.
- W2114944279 cites W1970988620 @default.
- W2114944279 cites W1971460830 @default.
- W2114944279 cites W1971726501 @default.
- W2114944279 cites W1979916898 @default.
- W2114944279 cites W2003226940 @default.
- W2114944279 cites W2003263626 @default.
- W2114944279 cites W2003418600 @default.
- W2114944279 cites W2003963272 @default.
- W2114944279 cites W2006723371 @default.
- W2114944279 cites W2014700267 @default.
- W2114944279 cites W2018632282 @default.
- W2114944279 cites W2021560851 @default.
- W2114944279 cites W2025922556 @default.
- W2114944279 cites W2026791237 @default.
- W2114944279 cites W2027381516 @default.
- W2114944279 cites W2027834423 @default.
- W2114944279 cites W2028389103 @default.
- W2114944279 cites W2035227348 @default.
- W2114944279 cites W2037127543 @default.
- W2114944279 cites W2038198389 @default.
- W2114944279 cites W2042394092 @default.
- W2114944279 cites W2049373941 @default.
- W2114944279 cites W2049446938 @default.
- W2114944279 cites W2050405445 @default.
- W2114944279 cites W2050448117 @default.
- W2114944279 cites W2053992818 @default.
- W2114944279 cites W2055082479 @default.
- W2114944279 cites W2059631748 @default.
- W2114944279 cites W2060037353 @default.
- W2114944279 cites W2060481603 @default.
- W2114944279 cites W2062060692 @default.
- W2114944279 cites W2064996657 @default.
- W2114944279 cites W2065628230 @default.
- W2114944279 cites W2066228936 @default.
- W2114944279 cites W2069924791 @default.
- W2114944279 cites W2075037447 @default.
- W2114944279 cites W2075059538 @default.
- W2114944279 cites W2077442850 @default.
- W2114944279 cites W2081341956 @default.
- W2114944279 cites W2081398748 @default.
- W2114944279 cites W2082993613 @default.
- W2114944279 cites W2084453514 @default.
- W2114944279 cites W2086201901 @default.
- W2114944279 cites W2089067113 @default.
- W2114944279 cites W2091947792 @default.
- W2114944279 cites W2093360069 @default.
- W2114944279 cites W2097127113 @default.
- W2114944279 cites W2097983973 @default.
- W2114944279 cites W2100536066 @default.
- W2114944279 cites W2109341154 @default.
- W2114944279 cites W2111848990 @default.
- W2114944279 cites W2114272370 @default.
- W2114944279 cites W2118105142 @default.
- W2114944279 cites W2120677058 @default.
- W2114944279 cites W2121619336 @default.
- W2114944279 cites W2124680162 @default.
- W2114944279 cites W2126385616 @default.
- W2114944279 cites W2128507820 @default.
- W2114944279 cites W2130206826 @default.
- W2114944279 cites W2134193049 @default.
- W2114944279 cites W2134234064 @default.
- W2114944279 cites W2138450760 @default.
- W2114944279 cites W2143352223 @default.
- W2114944279 cites W2146411771 @default.
- W2114944279 cites W2146577564 @default.
- W2114944279 cites W2148912710 @default.
- W2114944279 cites W2149024246 @default.
- W2114944279 cites W2150692944 @default.
- W2114944279 cites W2153157667 @default.
- W2114944279 cites W2155866564 @default.
- W2114944279 cites W2156554003 @default.
- W2114944279 cites W2156809732 @default.
- W2114944279 cites W2157503003 @default.
- W2114944279 cites W2159875343 @default.
- W2114944279 cites W2161028038 @default.
- W2114944279 cites W2163340289 @default.
- W2114944279 cites W2164096268 @default.
- W2114944279 cites W2164390107 @default.
- W2114944279 cites W2167098291 @default.
- W2114944279 cites W2399388342 @default.
- W2114944279 cites W2548946619 @default.
- W2114944279 doi "https://doi.org/10.2217/pgs.10.184" @default.
- W2114944279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21332316" @default.
- W2114944279 hasPublicationYear "2011" @default.
- W2114944279 type Work @default.
- W2114944279 sameAs 2114944279 @default.
- W2114944279 citedByCount "31" @default.
- W2114944279 countsByYear W21149442792012 @default.