Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114956112> ?p ?o ?g. }
- W2114956112 endingPage "2714" @default.
- W2114956112 startingPage "2705" @default.
- W2114956112 abstract "Overexpression of elongation factor-1 alpha (EF1 alpha) mRNA has been correlated with increased metastatic potential in mammary adenocarcinoma; however, this relationship was not explored at the level of protein expression. As EF1 alpha has been shown in other cell types to be a component of the actin cytoskeleton, a likely effector in metastasis, the actin binding activity of EF1 alpha from metastatic and nonmetastatic rat breast tumors and cell lines was investigated. We have shown that EF1 alpha protein is overexpressed in metastatic compared to nonmetastatic cells and whole tumors. Similarly to other EF1 alpha s, both types of tumor EF1 alpha bind to F-actin, but EF1 alpha from metastatic cells has a reduced affinity for actin. In addition, there is a high correlation between the intracellular distribution of filamentous actin and EF1 alpha in those cytoskeletal structures thought to be important for supporting the cellular motility required for metastasis. Following stimulation with EGF, there is a parallel increase in the amount of F-actin and EF1 alpha associated with the cytoskeleton. The response to EGF can be blocked with cytochalasin D indicating that the binding of EF1 alpha to the cytoskeleton is mediated by F-actin. We propose that a weakened association of EF1 alpha with actin may be related to the metastatic process via an altered organization of the actin cytoskeleton and the differential translation of mRNAs associated with the cytoskeleton." @default.
- W2114956112 created "2016-06-24" @default.
- W2114956112 creator A5014100567 @default.
- W2114956112 creator A5029282011 @default.
- W2114956112 creator A5033459315 @default.
- W2114956112 creator A5047900337 @default.
- W2114956112 creator A5057658236 @default.
- W2114956112 creator A5079001721 @default.
- W2114956112 creator A5079662311 @default.
- W2114956112 creator A5091538279 @default.
- W2114956112 date "1996-11-01" @default.
- W2114956112 modified "2023-10-10" @default.
- W2114956112 title "Elongation factor-1α is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma" @default.
- W2114956112 cites W1505024016 @default.
- W2114956112 cites W1520653386 @default.
- W2114956112 cites W1528921963 @default.
- W2114956112 cites W1557709748 @default.
- W2114956112 cites W1561143991 @default.
- W2114956112 cites W1566845757 @default.
- W2114956112 cites W1887739366 @default.
- W2114956112 cites W1895123982 @default.
- W2114956112 cites W1944821277 @default.
- W2114956112 cites W1965098419 @default.
- W2114956112 cites W1966601917 @default.
- W2114956112 cites W1976500290 @default.
- W2114956112 cites W1978773372 @default.
- W2114956112 cites W1983768617 @default.
- W2114956112 cites W1988377264 @default.
- W2114956112 cites W2002999352 @default.
- W2114956112 cites W2009668088 @default.
- W2114956112 cites W2022076737 @default.
- W2114956112 cites W2028317903 @default.
- W2114956112 cites W2032533515 @default.
- W2114956112 cites W2035048086 @default.
- W2114956112 cites W2035805550 @default.
- W2114956112 cites W2038540540 @default.
- W2114956112 cites W2044629144 @default.
- W2114956112 cites W2046771434 @default.
- W2114956112 cites W2050231926 @default.
- W2114956112 cites W2054423944 @default.
- W2114956112 cites W2060891667 @default.
- W2114956112 cites W2063890725 @default.
- W2114956112 cites W2066108081 @default.
- W2114956112 cites W2080128188 @default.
- W2114956112 cites W2085711791 @default.
- W2114956112 cites W2105416994 @default.
- W2114956112 cites W2121375446 @default.
- W2114956112 cites W2124642745 @default.
- W2114956112 cites W2133176205 @default.
- W2114956112 cites W2138333118 @default.
- W2114956112 cites W2157713791 @default.
- W2114956112 cites W2163152877 @default.
- W2114956112 cites W4253894943 @default.
- W2114956112 doi "https://doi.org/10.1242/jcs.109.11.2705" @default.
- W2114956112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8937988" @default.
- W2114956112 hasPublicationYear "1996" @default.
- W2114956112 type Work @default.
- W2114956112 sameAs 2114956112 @default.
- W2114956112 citedByCount "133" @default.
- W2114956112 countsByYear W21149561122012 @default.
- W2114956112 countsByYear W21149561122013 @default.
- W2114956112 countsByYear W21149561122014 @default.
- W2114956112 countsByYear W21149561122015 @default.
- W2114956112 countsByYear W21149561122016 @default.
- W2114956112 countsByYear W21149561122017 @default.
- W2114956112 countsByYear W21149561122018 @default.
- W2114956112 countsByYear W21149561122019 @default.
- W2114956112 countsByYear W21149561122020 @default.
- W2114956112 countsByYear W21149561122021 @default.
- W2114956112 countsByYear W21149561122022 @default.
- W2114956112 crossrefType "journal-article" @default.
- W2114956112 hasAuthorship W2114956112A5014100567 @default.
- W2114956112 hasAuthorship W2114956112A5029282011 @default.
- W2114956112 hasAuthorship W2114956112A5033459315 @default.
- W2114956112 hasAuthorship W2114956112A5047900337 @default.
- W2114956112 hasAuthorship W2114956112A5057658236 @default.
- W2114956112 hasAuthorship W2114956112A5079001721 @default.
- W2114956112 hasAuthorship W2114956112A5079662311 @default.
- W2114956112 hasAuthorship W2114956112A5091538279 @default.
- W2114956112 hasConcept C104317684 @default.
- W2114956112 hasConcept C125705527 @default.
- W2114956112 hasConcept C130861313 @default.
- W2114956112 hasConcept C142669718 @default.
- W2114956112 hasConcept C1491633281 @default.
- W2114956112 hasConcept C159110408 @default.
- W2114956112 hasConcept C2775944032 @default.
- W2114956112 hasConcept C2993400109 @default.
- W2114956112 hasConcept C49453240 @default.
- W2114956112 hasConcept C55493867 @default.
- W2114956112 hasConcept C58207958 @default.
- W2114956112 hasConcept C64943373 @default.
- W2114956112 hasConcept C67705224 @default.
- W2114956112 hasConcept C71924100 @default.
- W2114956112 hasConcept C75186080 @default.
- W2114956112 hasConcept C79879829 @default.
- W2114956112 hasConcept C86803240 @default.
- W2114956112 hasConcept C88478588 @default.
- W2114956112 hasConcept C95444343 @default.