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- W2114974209 abstract "Various analogues of the marine alkaloids, discorhabdins, have been synthesized. The strategy contains spirocyclization with phenyliodine(III) bis(trifluoroacetate) (PIFA), oxidative fragmentation of the β-amino alcohols with the hypervalent iodine reagent C(6)F(5)I(OCOCF(3))(2), the detosylation and dehydrogenation reaction of the pyrroloiminoquinone unit in the presence of a catalytic amount of NaN(3) and the bridged ether synthesis with HBr-AcOH as the key reactions. All the synthesized compounds were evaluated by in vitro MTT assay for cytotoxic activity against the human colon cancer cell line HCT-116. Furthermore, the discorhabdin A oxa analogues were also evaluated against four kinds of tumor model cells, a human colon cancer cell line (WiDr), a human prostate cancer cell line (DU-145) and murine leukemia cell lines (P388 and L1210). For the identification of the target, discorhabdin A and the discorhabdin A oxa analogue were evaluated by an HCC panel assay. In the test, discorhabdins could have a novel mode of action with the tumor cells." @default.
- W2114974209 created "2016-06-24" @default.
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- W2114974209 date "2011-01-01" @default.
- W2114974209 modified "2023-09-30" @default.
- W2114974209 title "The synthetic and biological studies of discorhabdins and related compounds" @default.
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- W2114974209 doi "https://doi.org/10.1039/c1ob05058c" @default.
- W2114974209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21597627" @default.
- W2114974209 hasPublicationYear "2011" @default.
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