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- W2114994111 abstract "A simple, efficient and reproducible reverse phase high performance liquid chromatographic method was developed and validated for the Simultaneous determination of cefixime (CEF) and moxifloxacin (MOX) in combined dosage form. Chromatographicseparationofthetwo drugswasperformedonaPurospherBDSC18 column(250mm×4.6mmid, 5µm particlesize). The mobile phase comprising of acetonitrile and 0.01M KH2PO4 in a ratio of 40:60 v/v at a flow rate of 1.0ml/min. The detection was made at 276 nm. The retention time of cefixime and moxifloxacin was found to be 3.140± 0.007min and 7.007± 0.006min. Calibration curve was linear over the concentration range of 20-120 µg/ml for both cefixime and moxifloxacin .All the analytical validation parameters were determined and found in the limit as per ICH guidelines, which indicate the validity of the method. The developed method is also found to be precise, accurate, specific, robust and rapid for the simultaneous determination of cefixime and moxifloxacin in tablet dosage forms." @default.
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- W2114994111 date "2012-12-22" @default.
- W2114994111 modified "2023-09-25" @default.
- W2114994111 title "Simultaneous Estimation of Cefixime and Moxifloxacin in Bulk and its Pharmaceutical Dosage form by RP-HPLC" @default.
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- W2114994111 doi "https://doi.org/10.13005/ojc/280425" @default.
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