FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115005005> ?p ?o ?g. }

• W2115005005 endingPage "11602" @default.
• W2115005005 startingPage "11594" @default.
• W2115005005 abstract "The hematological abnormalities observed in human immunodeficiency virus (HIV)-infected patients appear to be mainly due to bone marrow dysfunction. A macaque models of AIDS could greatly facilitate an in vivo approach to the pathogenesis of such dysfunction. Here, we evaluated in this model the impact of infection with a pathogenic simian/human immunodeficiency virus (SHIV) on bone marrow hematopoiesis. Three groups of macaques were inoculated with 50 50% median infective doses of pathogenic SHIV 89.P, which expresses env of dual-tropic HIV type 1 (HIV-1) 89.6 primary isolate. During the primary phase of infection, animals were treated with either a placebo or highly active antiretroviral therapy (HAART) combining zidovudine, lamivudine, and indinavir, initiated 4 or 72 h postinfection (p.i.) and administered twice a day until day 28 p.i. In both placebo-treated and HAART-treated animals, bone marrow colony-forming cells (CFC) progressively decreased quite early, during the first month p.i. One year p.i., both placebo- and HAART-treated animals displayed decreases in CFC to about 56% of preinfection values. At the same time, a dramatic decrease (greater than 77%) of bone marrow CD34(+) long-term culture-initiating cells was noted in all animals were found. No statistically significant differences between placebo- and HAART-treated monkeys were found. These data argue for an early and profound alteration of myelopoiesis at the level of the most primitive CD34(+) progenitor cells during SHIV infection, independently of the level of viremia, circulating CD4(+) cell counts, or antiviral treatment." @default.
• W2115005005 created "2016-06-24" @default.
• W2115005005 creator A5024435339 @default.
• W2115005005 creator A5031789027 @default.
• W2115005005 creator A5032170909 @default.
• W2115005005 creator A5046391226 @default.
• W2115005005 creator A5063568348 @default.
• W2115005005 creator A5063627180 @default.
• W2115005005 creator A5069149045 @default.
• W2115005005 creator A5077897116 @default.
• W2115005005 creator A5079128484 @default.
• W2115005005 date "2001-12-01" @default.
• W2115005005 modified "2023-10-17" @default.
• W2115005005 title "Early and Persistent Bone Marrow Hematopoiesis Defect in Simian/Human Immunodeficiency Virus-Infected Macaques despite Efficient Reduction of Viremia by Highly Active Antiretroviral Therapy during Primary Infection" @default.
• W2115005005 cites W130373832 @default.
• W2115005005 cites W131495626 @default.
• W2115005005 cites W1485158196 @default.
• W2115005005 cites W1558296954 @default.
• W2115005005 cites W1576259632 @default.
• W2115005005 cites W1586476245 @default.
• W2115005005 cites W1757653714 @default.
• W2115005005 cites W1835910353 @default.
• W2115005005 cites W1872848735 @default.
• W2115005005 cites W1975210238 @default.
• W2115005005 cites W1978857430 @default.
• W2115005005 cites W1980203367 @default.
• W2115005005 cites W1980782206 @default.
• W2115005005 cites W1983671664 @default.
• W2115005005 cites W1984593571 @default.
• W2115005005 cites W1992842828 @default.
• W2115005005 cites W1993431179 @default.
• W2115005005 cites W2007972342 @default.
• W2115005005 cites W2009094198 @default.
• W2115005005 cites W2013814144 @default.
• W2115005005 cites W2022851170 @default.
• W2115005005 cites W2028362497 @default.
• W2115005005 cites W2028896036 @default.
• W2115005005 cites W2029812035 @default.
• W2115005005 cites W2075585445 @default.
• W2115005005 cites W2084745098 @default.
• W2115005005 cites W2089985754 @default.
• W2115005005 cites W2094996578 @default.
• W2115005005 cites W2111102624 @default.
• W2115005005 cites W2120593002 @default.
• W2115005005 cites W2137813262 @default.
• W2115005005 cites W2139989999 @default.
• W2115005005 cites W214224763 @default.
• W2115005005 cites W2152513004 @default.
• W2115005005 cites W2167037373 @default.
• W2115005005 cites W2178218273 @default.
• W2115005005 cites W226476106 @default.
• W2115005005 cites W2317998198 @default.
• W2115005005 cites W2340198715 @default.
• W2115005005 cites W2394720881 @default.
• W2115005005 cites W2395999393 @default.
• W2115005005 cites W2398146302 @default.
• W2115005005 cites W2410783357 @default.
• W2115005005 cites W2412415797 @default.
• W2115005005 cites W2464375495 @default.
• W2115005005 cites W2474650552 @default.
• W2115005005 cites W4229510687 @default.
• W2115005005 cites W4234260999 @default.
• W2115005005 cites W4300924105 @default.
• W2115005005 cites W4322388503 @default.
• W2115005005 doi "https://doi.org/10.1128/jvi.75.23.11594-11602.2001" @default.
• W2115005005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/114746" @default.
• W2115005005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11689641" @default.
• W2115005005 hasPublicationYear "2001" @default.
• W2115005005 type Work @default.
• W2115005005 sameAs 2115005005 @default.
• W2115005005 citedByCount "43" @default.
• W2115005005 countsByYear W21150050052012 @default.
• W2115005005 countsByYear W21150050052013 @default.
• W2115005005 countsByYear W21150050052015 @default.
• W2115005005 countsByYear W21150050052016 @default.
• W2115005005 countsByYear W21150050052019 @default.
• W2115005005 countsByYear W21150050052021 @default.
• W2115005005 countsByYear W21150050052022 @default.
• W2115005005 crossrefType "journal-article" @default.
• W2115005005 hasAuthorship W2115005005A5024435339 @default.
• W2115005005 hasAuthorship W2115005005A5031789027 @default.
• W2115005005 hasAuthorship W2115005005A5032170909 @default.
• W2115005005 hasAuthorship W2115005005A5046391226 @default.
• W2115005005 hasAuthorship W2115005005A5063568348 @default.
• W2115005005 hasAuthorship W2115005005A5063627180 @default.
• W2115005005 hasAuthorship W2115005005A5069149045 @default.
• W2115005005 hasAuthorship W2115005005A5077897116 @default.
• W2115005005 hasAuthorship W2115005005A5079128484 @default.
• W2115005005 hasBestOaLocation W21150050051 @default.
• W2115005005 hasConcept C109159458 @default.
• W2115005005 hasConcept C151730666 @default.
• W2115005005 hasConcept C159047783 @default.
• W2115005005 hasConcept C203014093 @default.
• W2115005005 hasConcept C2522874641 @default.
• W2115005005 hasConcept C2776185481 @default.
• W2115005005 hasConcept C2776452011 @default.
• W2115005005 hasConcept C2777210460 @default.
• W2115005005 hasConcept C2777995582 @default.

• next