Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115005877> ?p ?o ?g. }
- W2115005877 endingPage "2361" @default.
- W2115005877 startingPage "2351" @default.
- W2115005877 abstract "Abstract Topology has been shown to be an important determinant of many features of protein folding; however, the delineation of sequence effects on folding remains obscure. Furthermore, differentiation between the two influences proves difficult due to their intimate relationship. To investigate the effect of sequence in the absence of significant topological differences, we examined the folding mechanisms of segment B1 peptostreptococcal protein L and segment B1 of streptococcal protein G. These proteins share the same highly symmetrical topology. Despite this symmetry, neither protein folds through a symmetrical transition state. We analyzed the origins of this difference using theoretical models. We found that the strength of the interactions present in the N‐terminal hairpin of protein L causes this hairpin to form ahead of the C‐terminal hairpin. The difference in chain entropy associated with the formation of the hairpins of protein G proves sufficient to beget initiation of folding at the shorter C‐terminal hairpin. Our findings suggest that the mechanism of folding may be understood by examination of the free energy associated with the formation of partially folded microstates." @default.
- W2115005877 created "2016-06-24" @default.
- W2115005877 creator A5060440052 @default.
- W2115005877 creator A5087413939 @default.
- W2115005877 date "2002-10-01" @default.
- W2115005877 modified "2023-10-11" @default.
- W2115005877 title "The origins of asymmetry in the folding transition states of protein L and protein G" @default.
- W2115005877 cites W1481744725 @default.
- W2115005877 cites W1505900198 @default.
- W2115005877 cites W1526967281 @default.
- W2115005877 cites W1550166367 @default.
- W2115005877 cites W1557890208 @default.
- W2115005877 cites W1561923743 @default.
- W2115005877 cites W1570122994 @default.
- W2115005877 cites W1593625064 @default.
- W2115005877 cites W1966041739 @default.
- W2115005877 cites W1980014445 @default.
- W2115005877 cites W1987450816 @default.
- W2115005877 cites W1989297730 @default.
- W2115005877 cites W1990644981 @default.
- W2115005877 cites W1993321394 @default.
- W2115005877 cites W1999152484 @default.
- W2115005877 cites W2008708467 @default.
- W2115005877 cites W2009929688 @default.
- W2115005877 cites W2020716464 @default.
- W2115005877 cites W2021002797 @default.
- W2115005877 cites W2027095682 @default.
- W2115005877 cites W2028231353 @default.
- W2115005877 cites W2029927731 @default.
- W2115005877 cites W2032008622 @default.
- W2115005877 cites W2036623301 @default.
- W2115005877 cites W2040809566 @default.
- W2115005877 cites W2041149980 @default.
- W2115005877 cites W2043579587 @default.
- W2115005877 cites W2044864889 @default.
- W2115005877 cites W2045126466 @default.
- W2115005877 cites W2048859046 @default.
- W2115005877 cites W2051039246 @default.
- W2115005877 cites W2051714667 @default.
- W2115005877 cites W2056528113 @default.
- W2115005877 cites W2057236272 @default.
- W2115005877 cites W2064589158 @default.
- W2115005877 cites W2064931749 @default.
- W2115005877 cites W2065268320 @default.
- W2115005877 cites W2072261891 @default.
- W2115005877 cites W2076488922 @default.
- W2115005877 cites W2079697713 @default.
- W2115005877 cites W2082296224 @default.
- W2115005877 cites W2085142174 @default.
- W2115005877 cites W2088809689 @default.
- W2115005877 cites W2088981849 @default.
- W2115005877 cites W2089597488 @default.
- W2115005877 cites W2104704906 @default.
- W2115005877 cites W2106140689 @default.
- W2115005877 cites W2112032866 @default.
- W2115005877 cites W2113449266 @default.
- W2115005877 cites W2120451413 @default.
- W2115005877 cites W2131982602 @default.
- W2115005877 cites W2138605281 @default.
- W2115005877 cites W2145010489 @default.
- W2115005877 cites W2147396853 @default.
- W2115005877 cites W2162166182 @default.
- W2115005877 cites W2165222310 @default.
- W2115005877 cites W2171546617 @default.
- W2115005877 doi "https://doi.org/10.1110/ps.0205402" @default.
- W2115005877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2373711" @default.
- W2115005877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12237457" @default.
- W2115005877 hasPublicationYear "2002" @default.
- W2115005877 type Work @default.
- W2115005877 sameAs 2115005877 @default.
- W2115005877 citedByCount "352" @default.
- W2115005877 countsByYear W21150058772012 @default.
- W2115005877 countsByYear W21150058772013 @default.
- W2115005877 countsByYear W21150058772014 @default.
- W2115005877 countsByYear W21150058772015 @default.
- W2115005877 countsByYear W21150058772016 @default.
- W2115005877 countsByYear W21150058772017 @default.
- W2115005877 countsByYear W21150058772018 @default.
- W2115005877 countsByYear W21150058772019 @default.
- W2115005877 countsByYear W21150058772020 @default.
- W2115005877 countsByYear W21150058772021 @default.
- W2115005877 countsByYear W21150058772022 @default.
- W2115005877 countsByYear W21150058772023 @default.
- W2115005877 crossrefType "journal-article" @default.
- W2115005877 hasAuthorship W2115005877A5060440052 @default.
- W2115005877 hasAuthorship W2115005877A5087413939 @default.
- W2115005877 hasBestOaLocation W21150058771 @default.
- W2115005877 hasConcept C106301342 @default.
- W2115005877 hasConcept C114614502 @default.
- W2115005877 hasConcept C119599485 @default.
- W2115005877 hasConcept C121332964 @default.
- W2115005877 hasConcept C12554922 @default.
- W2115005877 hasConcept C127413603 @default.
- W2115005877 hasConcept C184720557 @default.
- W2115005877 hasConcept C185592680 @default.
- W2115005877 hasConcept C204328495 @default.
- W2115005877 hasConcept C206276672 @default.
- W2115005877 hasConcept C2776545253 @default.