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- W2115013553 abstract "Dementia with Lewy Bodies (DLB) patients often exhibit attentional, visuospatial and executive deficits, consistent with frontal and parieto-occipital neuropathological abnormalities well described in this disease. Less is known about the impairment of eye movement control, as well as of early and dorsal visual functions and the specificity of this kind of disregulation in DLB. Using a battery of neuropsychological and psychophysical tests, we aim to explore cognitive and visual abnormalities in patients with DLB and compare them with Alzheimer's Disease (AD). Twenty DLB patients, previously diagnosed following international consensus criteria (McKeith, et. al, 1996), twenty AD patients diagnosed according NINCDS-ADRDA, as well as a control group (N = 20), were recruited. Both groups of patients were matched for age, educational level and severity of the disease. All subjects were assessed with a battery of cognitive tests: Stroop Colour Test, Trail Making Test, Verbal Fluency Test, Luria's Graphmotor Sequences and Reaction Time Test (RTI)-CANTAB. Participants without retinal pathology underwent visual function assessment with psychophysical tests: Local Speed Discrimination (LSD), Structure-From-Motion (SFM) perception and a Contrast Sensitivity (CS) test with eye movement measurements to control for fixation and saccadic patterns potentially evoked by visual pre-cues. Patients were also assessed with motor, neuropsychiatric and fluctuation scales. When compared with the control group, both groups of patients (DLB and AD) performed globally worse in cognitive and visual tasks. DLB patients showed less positional accuracy in RTI task than AD patients. Regarding eye movement patterns, DLB patients were less able to maintain fixation in the CS task, in the presence of target pre-cues. DLB and AD patients demonstrated similar cognitive performance and equivalent impairment in early and dorsal visual functions. These results do therefore suggest that both diseases affect occipital networks involved in contrast sensitivity and motion perception in a similar manner. However, in what concerns to eye movement control, DLB patients are characterized by a significant inability to sustain fixation, which was the biomarker that differentiated the two groups." @default.
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- W2115013553 date "2010-07-01" @default.
- W2115013553 modified "2023-10-16" @default.
- W2115013553 title "P1-024: Visual and cognitive impairment in patients with dementia with Lewy bodies and Alzheimer's disease" @default.
- W2115013553 doi "https://doi.org/10.1016/j.jalz.2010.05.571" @default.
- W2115013553 hasPublicationYear "2010" @default.
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