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• W2115043517 abstract "The enterococcal surface protein Esp, specifically linked to nosocomial Enterococcus faecium, is involved in biofilm formation. To assess the role of Esp in endocarditis, a biofilm-associated infection, an Esp-expressing E. faecium strain (E1162) or its Esp-deficient mutant (E1162Δesp) were inoculated through a catheter into the left ventricle of rats. After 24 h, less E1162Δesp than E1162 were recovered from heart valve vegetations. In addition, anti-Esp antibodies were detected in Esp-positive E. faecium bacteremia and endocarditis patient sera. In conclusion, Esp contributes to colonization of E. faecium at the heart valves. Furthermore, systemic infection elicits an Esp-specific antibody response in humans." @default.
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• W2115043517 date "2011-12-01" @default.
• W2115043517 modified "2023-10-13" @default.
• W2115043517 title "Contribution of the enterococcal surface protein Esp to pathogenesis of Enterococcus faecium endocarditis" @default.
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• W2115043517 doi "https://doi.org/10.1016/j.micinf.2011.08.006" @default.
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