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- W2115043766 abstract "Prostate cancer remains a significant health concern for men throughout the world. Recently, there has developed an expanding multidisciplinary body of literature suggesting a link between chronic inflammation and prostate cancer. In support of this hypothesis, population studies have found an increased relative risk of prostate cancer in men with a prior history of certain sexually transmitted infections or prostatitis. Furthermore, genetic epidemiological data have implicated germline variants of several genes associated with the immunological aspects of inflammation in modulating prostate cancer risk. The molecular pathogenesis of prostate cancer has been characterized by somatic alterations of genes involved in defenses against inflammatory damage and in tissue recovery. A novel putative prostate cancer precursor lesion, proliferative inflammatory atrophy, which shares some molecular traits with prostate intraepithelial neoplasia and prostate cancer, has been characterized. Here, we review the evidence associating chronic inflammation and prostate cancer and consider a number of animal models of prostate inflammation that should allow the elucidation of the mechanisms by which prostatic inflammation could lead to the initiation and progression of prostate cancer. These emerging insights into chronic inflammation in the etiology of prostate carcinogenesis hold the promise of spawning new diagnostic and therapeutic modalities for men with prostate cancer." @default.
- W2115043766 created "2016-06-24" @default.
- W2115043766 creator A5021386247 @default.
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- W2115043766 date "2004-10-21" @default.
- W2115043766 modified "2023-10-14" @default.
- W2115043766 title "Prostate carcinogenesis and inflammation: emerging insights" @default.
- W2115043766 cites W107315917 @default.
- W2115043766 cites W151500627 @default.
- W2115043766 cites W1550721230 @default.
- W2115043766 cites W1552119358 @default.
- W2115043766 cites W1580316843 @default.
- W2115043766 cites W1593840699 @default.
- W2115043766 cites W1657916452 @default.
- W2115043766 cites W1821918060 @default.
- W2115043766 cites W1862601732 @default.
- W2115043766 cites W1872583110 @default.
- W2115043766 cites W1965037168 @default.
- W2115043766 cites W1965103420 @default.
- W2115043766 cites W1968391853 @default.
- W2115043766 cites W1968899198 @default.
- W2115043766 cites W1969962178 @default.
- W2115043766 cites W1973730356 @default.
- W2115043766 cites W1974899108 @default.
- W2115043766 cites W1978373343 @default.
- W2115043766 cites W1986201328 @default.
- W2115043766 cites W1987395035 @default.
- W2115043766 cites W1987769833 @default.
- W2115043766 cites W1988525082 @default.
- W2115043766 cites W1991623479 @default.
- W2115043766 cites W1993923853 @default.
- W2115043766 cites W1995604720 @default.
- W2115043766 cites W1997517088 @default.
- W2115043766 cites W1998430784 @default.
- W2115043766 cites W2000728485 @default.
- W2115043766 cites W2001872687 @default.
- W2115043766 cites W2003482728 @default.
- W2115043766 cites W2003696158 @default.
- W2115043766 cites W2004797953 @default.
- W2115043766 cites W2006052818 @default.
- W2115043766 cites W2007208883 @default.
- W2115043766 cites W2010998376 @default.
- W2115043766 cites W2013743651 @default.
- W2115043766 cites W2015080686 @default.
- W2115043766 cites W2021812214 @default.
- W2115043766 cites W2023518603 @default.
- W2115043766 cites W2027782184 @default.
- W2115043766 cites W2027981798 @default.
- W2115043766 cites W2029782698 @default.
- W2115043766 cites W2030552125 @default.
- W2115043766 cites W2032560153 @default.
- W2115043766 cites W2035815966 @default.
- W2115043766 cites W2036131420 @default.
- W2115043766 cites W2037956917 @default.
- W2115043766 cites W2039361749 @default.
- W2115043766 cites W2043934814 @default.
- W2115043766 cites W2044615475 @default.
- W2115043766 cites W2046306735 @default.
- W2115043766 cites W2047375672 @default.
- W2115043766 cites W2049848204 @default.
- W2115043766 cites W205075771 @default.
- W2115043766 cites W2052253385 @default.
- W2115043766 cites W2053548194 @default.
- W2115043766 cites W2054751745 @default.
- W2115043766 cites W2055786885 @default.
- W2115043766 cites W205639803 @default.
- W2115043766 cites W2056501152 @default.
- W2115043766 cites W2058680827 @default.
- W2115043766 cites W2061633878 @default.
- W2115043766 cites W2062006040 @default.
- W2115043766 cites W2062676201 @default.
- W2115043766 cites W2062822134 @default.
- W2115043766 cites W2063297071 @default.
- W2115043766 cites W2064117760 @default.
- W2115043766 cites W2064577378 @default.
- W2115043766 cites W2067581674 @default.
- W2115043766 cites W2067847877 @default.
- W2115043766 cites W2068075238 @default.
- W2115043766 cites W2068751000 @default.
- W2115043766 cites W2068813226 @default.
- W2115043766 cites W2069027839 @default.
- W2115043766 cites W2069205400 @default.
- W2115043766 cites W2070165592 @default.
- W2115043766 cites W2072760602 @default.
- W2115043766 cites W2078747897 @default.
- W2115043766 cites W2078939459 @default.
- W2115043766 cites W2081558365 @default.
- W2115043766 cites W2081628690 @default.
- W2115043766 cites W2082844215 @default.
- W2115043766 cites W2083061425 @default.
- W2115043766 cites W2086478724 @default.
- W2115043766 cites W2087321474 @default.
- W2115043766 cites W2088172693 @default.