FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115044453> ?p ?o ?g. }

• W2115044453 endingPage "1309" @default.
• W2115044453 startingPage "1309" @default.
• W2115044453 abstract "• Progressive cell injury occurs with shock and ischemia, beginning with functional changes in the cell and cell membrane. Membrane transport and potential decrease, Na⁺enters and K⁺leaves cells; Na⁺-K⁺adenosine triphosphatase is activated, adenosine triphosphate (ATP) is used, and mitochondria are stimulated as increased lactate produces acidosis. Energy and cyclic adenosine monophosphate levels decrease, Ca²⁺regulation is compromised, and nuclear function and protein synthesis are depressed. The cell swells, and further membrane changes occur with altered hormonal effects and mitochondrial uncoupling. Finally, lysosomes leak, intracellular and mitochondria disruption occurs, and the cell is destroyed. Based on these changes, attempts were made to directly support cell function during low-flow states. After volume replacement and vasoactive agents, other modalities, eg, substrates, membrane-stabilizing solutions, osmotic agents, and energy compounds were used. The use of ATP-MgCl₂was helpful in many experimental low-flow states, with an improvement in cell function mediated by micro-circulatory, cell membrane, or energy-recycling effects. Clinical examples of altered cell and organ function with ischemia and shock are numerous and play a critical role in the development of multiple systems failure. The potential for biochemical support and correction of these problems is now recognized. Benefits have already been achieved in myocardial preservation during cardiac operations, kidney preservation for transplantation, and circulatory and metabolic support of the injured and septic patient. (<i>Arch Surg</i>1981;116:1309-1317)" @default.
• W2115044453 created "2016-06-24" @default.
• W2115044453 creator A5006751862 @default.
• W2115044453 creator A5028744164 @default.
• W2115044453 creator A5085171919 @default.
• W2115044453 date "1981-10-01" @default.
• W2115044453 modified "2023-09-23" @default.
• W2115044453 title "Alterations in Cell Function With Ischemia and Shock and Their Correction" @default.
• W2115044453 cites W126586749 @default.
• W2115044453 cites W1541690802 @default.
• W2115044453 cites W1579181700 @default.
• W2115044453 cites W1967775253 @default.
• W2115044453 cites W1976822419 @default.
• W2115044453 cites W1982709225 @default.
• W2115044453 cites W1983549873 @default.
• W2115044453 cites W1986798649 @default.
• W2115044453 cites W1986912238 @default.
• W2115044453 cites W1989514730 @default.
• W2115044453 cites W2000216627 @default.
• W2115044453 cites W2006111629 @default.
• W2115044453 cites W2008875776 @default.
• W2115044453 cites W2014261846 @default.
• W2115044453 cites W2024586647 @default.
• W2115044453 cites W2034885011 @default.
• W2115044453 cites W2035857494 @default.
• W2115044453 cites W2039936941 @default.
• W2115044453 cites W2043881219 @default.
• W2115044453 cites W2046152441 @default.
• W2115044453 cites W2058511233 @default.
• W2115044453 cites W2059391342 @default.
• W2115044453 cites W2060043900 @default.
• W2115044453 cites W2062179976 @default.
• W2115044453 cites W2062734471 @default.
• W2115044453 cites W2066025440 @default.
• W2115044453 cites W2068720036 @default.
• W2115044453 cites W2069346220 @default.
• W2115044453 cites W2070292620 @default.
• W2115044453 cites W2073976965 @default.
• W2115044453 cites W2075563334 @default.
• W2115044453 cites W2078257287 @default.
• W2115044453 cites W2082169180 @default.
• W2115044453 cites W2083619724 @default.
• W2115044453 cites W2084700971 @default.
• W2115044453 cites W2084844888 @default.
• W2115044453 cites W2094739091 @default.
• W2115044453 cites W2101793795 @default.
• W2115044453 cites W2102645614 @default.
• W2115044453 cites W2105250578 @default.
• W2115044453 cites W2105771779 @default.
• W2115044453 cites W2134628028 @default.
• W2115044453 cites W2145670873 @default.
• W2115044453 cites W2200959820 @default.
• W2115044453 cites W2238254077 @default.
• W2115044453 cites W2278924823 @default.
• W2115044453 cites W2283755250 @default.
• W2115044453 cites W2333845729 @default.
• W2115044453 cites W2345950265 @default.
• W2115044453 cites W2395085322 @default.
• W2115044453 cites W2395663732 @default.
• W2115044453 cites W2396456602 @default.
• W2115044453 cites W2397491545 @default.
• W2115044453 cites W2400223895 @default.
• W2115044453 cites W2400359853 @default.
• W2115044453 cites W2401981830 @default.
• W2115044453 cites W2402280963 @default.
• W2115044453 cites W2407627168 @default.
• W2115044453 cites W2409993263 @default.
• W2115044453 cites W2410519949 @default.
• W2115044453 cites W2411119011 @default.
• W2115044453 cites W2412616238 @default.
• W2115044453 cites W2412858005 @default.
• W2115044453 cites W2413845731 @default.
• W2115044453 cites W2414047564 @default.
• W2115044453 cites W2414634590 @default.
• W2115044453 cites W2414878169 @default.
• W2115044453 cites W2416024222 @default.
• W2115044453 cites W2416688988 @default.
• W2115044453 cites W2417098392 @default.
• W2115044453 cites W2417830520 @default.
• W2115044453 cites W2419273674 @default.
• W2115044453 cites W2419569663 @default.
• W2115044453 cites W2419650732 @default.
• W2115044453 cites W341457271 @default.
• W2115044453 cites W57713311 @default.
• W2115044453 cites W2413208658 @default.
• W2115044453 cites W2423901501 @default.
• W2115044453 doi "https://doi.org/10.1001/archsurg.1981.01380220053009" @default.
• W2115044453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7025800" @default.
• W2115044453 hasPublicationYear "1981" @default.
• W2115044453 type Work @default.
• W2115044453 sameAs 2115044453 @default.
• W2115044453 citedByCount "77" @default.
• W2115044453 countsByYear W21150444532012 @default.
• W2115044453 countsByYear W21150444532014 @default.
• W2115044453 countsByYear W21150444532015 @default.
• W2115044453 countsByYear W21150444532016 @default.
• W2115044453 countsByYear W21150444532017 @default.
• W2115044453 countsByYear W21150444532019 @default.

• next