FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115055402> ?p ?o ?g. }

• W2115055402 endingPage "345" @default.
• W2115055402 startingPage "337" @default.
• W2115055402 abstract "Gingival fibroblasts (GFs) produce pro-inflammatory cytokines in response to stimulation with lipopolysaccharide (LPS) of Porphyromonas gingivalis, which is thought to be mediated by activation of toll-like receptors (TLR)2 and TLR4. The present study investigated the expression of interleukin (IL)-6, TLR2, and TLR4 in GFs of seven different donors upon stimulation with P. gingivalis LPS. The effects of P. gingivalis LPS were compared with those of TLR4 agonist Escherichia coli LPS and TLR2 agonist Pam3CSK4.GFs were stimulated with P. gingivalis LPS, E. coli LPS or Pam3CSK4 and the expression of IL-6, TLR2 and TLR4 was measured by qPCR. The surface expression of TLR2 and TLR4 was measured by flow cytometry.In GFs from three donors, P. gingivalis LPS and Pam3CSK4 induced a markedly lower increase in IL-6 expression than E. coli LPS. This was accompanied by significant down-regulation of the TLR2 and TLR4 expression. In GFs from another four donors, an increase in IL-6 expression upon stimulation with P. gingivalis LPS and Pam3CSK4 was similar or even higher than that induced by E. coli LPS. In GFs of these donors, all stimuli induced an up-regulation of both mRNA and protein expression of TLR2 and did not influence that of TLR4.This study suggests that P. gingivalis LPS and E. coli LPS differently regulate cytokine production in human gingival fibroblasts. Regulation of the expression level of TLR2 and TLR4 by periodontal pathogens might be an important factor controlling the inflammatory response in GFs." @default.
• W2115055402 created "2016-06-24" @default.
• W2115055402 creator A5021548383 @default.
• W2115055402 creator A5032773909 @default.
• W2115055402 creator A5048952889 @default.
• W2115055402 creator A5078161780 @default.
• W2115055402 creator A5081692369 @default.
• W2115055402 date "2013-11-21" @default.
• W2115055402 modified "2023-09-26" @default.
• W2115055402 title "Different effects of<i>P. gingivalis</i>LPS and<i>E. coli</i>LPS on the expression of interleukin-6 in human gingival fibroblasts" @default.
• W2115055402 cites W1483162601 @default.
• W2115055402 cites W1834719122 @default.
• W2115055402 cites W1973251022 @default.
• W2115055402 cites W1976884474 @default.
• W2115055402 cites W1986974750 @default.
• W2115055402 cites W1999834156 @default.
• W2115055402 cites W2013144840 @default.
• W2115055402 cites W2017403582 @default.
• W2115055402 cites W2028009083 @default.
• W2115055402 cites W2029189520 @default.
• W2115055402 cites W2044620820 @default.
• W2115055402 cites W2052323412 @default.
• W2115055402 cites W2062086916 @default.
• W2115055402 cites W2070214421 @default.
• W2115055402 cites W2076357770 @default.
• W2115055402 cites W2080857291 @default.
• W2115055402 cites W2085902590 @default.
• W2115055402 cites W2098924752 @default.
• W2115055402 cites W2102855106 @default.
• W2115055402 cites W2105785789 @default.
• W2115055402 cites W2107715779 @default.
• W2115055402 cites W2111971681 @default.
• W2115055402 cites W2113225558 @default.
• W2115055402 cites W2115893060 @default.
• W2115055402 cites W2118050533 @default.
• W2115055402 cites W2119013116 @default.
• W2115055402 cites W2128492720 @default.
• W2115055402 cites W2136998027 @default.
• W2115055402 cites W2142784507 @default.
• W2115055402 cites W2144345929 @default.
• W2115055402 cites W2144868385 @default.
• W2115055402 cites W2151241369 @default.
• W2115055402 cites W2152409544 @default.
• W2115055402 cites W2155008443 @default.
• W2115055402 cites W2156445477 @default.
• W2115055402 cites W2157533197 @default.
• W2115055402 cites W2158776355 @default.
• W2115055402 cites W2170966854 @default.
• W2115055402 cites W2171811704 @default.
• W2115055402 cites W2291432374 @default.
• W2115055402 cites W4233511003 @default.
• W2115055402 cites W4249383371 @default.
• W2115055402 doi "https://doi.org/10.3109/00016357.2013.834535" @default.
• W2115055402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24255960" @default.
• W2115055402 hasPublicationYear "2013" @default.
• W2115055402 type Work @default.
• W2115055402 sameAs 2115055402 @default.
• W2115055402 citedByCount "53" @default.
• W2115055402 countsByYear W21150554022014 @default.
• W2115055402 countsByYear W21150554022015 @default.
• W2115055402 countsByYear W21150554022016 @default.
• W2115055402 countsByYear W21150554022017 @default.
• W2115055402 countsByYear W21150554022018 @default.
• W2115055402 countsByYear W21150554022019 @default.
• W2115055402 countsByYear W21150554022020 @default.
• W2115055402 countsByYear W21150554022021 @default.
• W2115055402 countsByYear W21150554022022 @default.
• W2115055402 countsByYear W21150554022023 @default.
• W2115055402 crossrefType "journal-article" @default.
• W2115055402 hasAuthorship W2115055402A5021548383 @default.
• W2115055402 hasAuthorship W2115055402A5032773909 @default.
• W2115055402 hasAuthorship W2115055402A5048952889 @default.
• W2115055402 hasAuthorship W2115055402A5078161780 @default.
• W2115055402 hasAuthorship W2115055402A5081692369 @default.
• W2115055402 hasConcept C126322002 @default.
• W2115055402 hasConcept C134018914 @default.
• W2115055402 hasConcept C136449434 @default.
• W2115055402 hasConcept C153911025 @default.
• W2115055402 hasConcept C170493617 @default.
• W2115055402 hasConcept C185592680 @default.
• W2115055402 hasConcept C203014093 @default.
• W2115055402 hasConcept C24998067 @default.
• W2115055402 hasConcept C2776070231 @default.
• W2115055402 hasConcept C2776709828 @default.
• W2115055402 hasConcept C2778690821 @default.
• W2115055402 hasConcept C2778754761 @default.
• W2115055402 hasConcept C2778938600 @default.
• W2115055402 hasConcept C2780183776 @default.
• W2115055402 hasConcept C2780385504 @default.
• W2115055402 hasConcept C2781236682 @default.
• W2115055402 hasConcept C71924100 @default.
• W2115055402 hasConcept C74172505 @default.
• W2115055402 hasConcept C86803240 @default.
• W2115055402 hasConcept C89423630 @default.
• W2115055402 hasConceptScore W2115055402C126322002 @default.
• W2115055402 hasConceptScore W2115055402C134018914 @default.
• W2115055402 hasConceptScore W2115055402C136449434 @default.
• W2115055402 hasConceptScore W2115055402C153911025 @default.

• next