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- W2115057306 abstract "Fertilized mammalian ova consist of haploid genomes derived from both parents and cytoplasmic components inherited largely from the female parent. These three cellular compartments must successfully interact with each other and with their environment for development to proceed. These interactions require the transposition of nuclear and cytoplasmic products between cellular compartments with resultant alteration of gene transcription and the cytoplasmic expression of preformed or newly synthesized gene products. We have investigated nuclear/cytoplasmic interactions in the mouse embryo via the microsurgical transfer of nuclei and cytoplasm. Experiments have specifically examined the ability of nuclei from later developmental stages or from a different species to support development, volume relationships between nuclear and cytoplasmic compartments, and the nonequivalency of the maternal and paternal genomic contributions to development.The ability of egg cytoplasm to alter the function of a variety of embryonic and adult nuclei and the ability of these nuclei to support development has been extensively tested in nuclear transplantation investigations in amphibian embryos." @default.
- W2115057306 created "2016-06-24" @default.
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- W2115057306 date "1986-10-01" @default.
- W2115057306 modified "2023-09-27" @default.
- W2115057306 title "Nucleocytoplasmic interactions in the mouse embryo" @default.
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- W2115057306 doi "https://doi.org/10.1242/dev.97.supplement.277" @default.
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