FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115059097> ?p ?o ?g. }

• W2115059097 endingPage "450" @default.
• W2115059097 startingPage "445" @default.
• W2115059097 abstract "Dibenzo[a,l]pyrene (DB[a,l]P) and benzo[a]pyrene (B[a]P) are carcinogenic polycyclic aromatic hydrocarbons (PAHs) that are each capable of forming a variety of covalent adducts with DNA. Some of the DNA adducts formed by these PAHs have been demonstrated to spontaneously depurinate, producing apurinic (AP) sites. The significance of the formation of AP sites as a key event in the production of mutations and tumours by PAHs has been a subject of ongoing investigations. Because cells have efficient and accurate mechanisms for repairing background levels of AP sites, the contribution of PAH-induced AP site mutagenesis is expected to be maximal in conditions where those induced AP sites are produced in significant excess of the endogenous AP sites. In this study, we investigated the effect of two dosing regimens on the mutagenicity of DB[a,l]P and B[a]P in vivo using the Big Blue® transgenic mouse system. We compared administration of a single highly tumorigenic dose of each PAH with a fractionated delivery of the same total dose administered over 5 days, with the expectation that PAH-induced AP sites would be produced at a greater margin above background levels in animals receiving the high single dose than in the animals receiving the fractionated doses. Treatment with DB[a,l]P yielded a 2.5-fold (single dose) to 3-fold (fractionated dose) increase in mutant frequencies relative to controls. Both single-dose and fractionated dose treatment regimens with B[a]P produced about a 15-fold increase in mutant frequencies compared to controls. The mutations induced by B[a]P and DB[a,l]P correlated with the stable covalent DNA adducts produced by each. These mutation results are consistent with the previously identified stable covalent DNA adducts being the promutagenic lesions produced by these two PAHs and do not support a major role for depurinating adducts, contributing to PAH-induced mutagenesis in mouse lung in vivo." @default.
• W2115059097 created "2016-06-24" @default.
• W2115059097 creator A5001345174 @default.
• W2115059097 creator A5072073488 @default.
• W2115059097 creator A5080154408 @default.
• W2115059097 creator A5082184442 @default.
• W2115059097 date "2008-08-04" @default.
• W2115059097 modified "2023-10-07" @default.
• W2115059097 title "Mutations induced by benzo[a]pyrene and dibenzo[a,l]pyrene in lacI transgenic B6C3F1 mouse lung result from stable DNA adducts" @default.
• W2115059097 cites W1973013917 @default.
• W2115059097 cites W1974418289 @default.
• W2115059097 cites W1974895075 @default.
• W2115059097 cites W1981153084 @default.
• W2115059097 cites W1986003168 @default.
• W2115059097 cites W1986860495 @default.
• W2115059097 cites W1997150474 @default.
• W2115059097 cites W2001222349 @default.
• W2115059097 cites W2007405710 @default.
• W2115059097 cites W2021750867 @default.
• W2115059097 cites W2024191382 @default.
• W2115059097 cites W2029518000 @default.
• W2115059097 cites W2030658954 @default.
• W2115059097 cites W2046638467 @default.
• W2115059097 cites W2054114446 @default.
• W2115059097 cites W2055118039 @default.
• W2115059097 cites W2065758000 @default.
• W2115059097 cites W2068132457 @default.
• W2115059097 cites W2074128797 @default.
• W2115059097 cites W2074396887 @default.
• W2115059097 cites W2075175811 @default.
• W2115059097 cites W2076519777 @default.
• W2115059097 cites W2098549869 @default.
• W2115059097 cites W2114700904 @default.
• W2115059097 cites W2155073279 @default.
• W2115059097 cites W2167463754 @default.
• W2115059097 cites W2169470627 @default.
• W2115059097 cites W2172233405 @default.
• W2115059097 cites W2414005403 @default.
• W2115059097 cites W4231668076 @default.
• W2115059097 doi "https://doi.org/10.1093/mutage/gen033" @default.
• W2115059097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18573814" @default.
• W2115059097 hasPublicationYear "2008" @default.
• W2115059097 type Work @default.
• W2115059097 sameAs 2115059097 @default.
• W2115059097 citedByCount "29" @default.
• W2115059097 countsByYear W21150590972012 @default.
• W2115059097 countsByYear W21150590972013 @default.
• W2115059097 countsByYear W21150590972014 @default.
• W2115059097 countsByYear W21150590972016 @default.
• W2115059097 countsByYear W21150590972017 @default.
• W2115059097 countsByYear W21150590972020 @default.
• W2115059097 countsByYear W21150590972021 @default.
• W2115059097 countsByYear W21150590972022 @default.
• W2115059097 crossrefType "journal-article" @default.
• W2115059097 hasAuthorship W2115059097A5001345174 @default.
• W2115059097 hasAuthorship W2115059097A5072073488 @default.
• W2115059097 hasAuthorship W2115059097A5080154408 @default.
• W2115059097 hasAuthorship W2115059097A5082184442 @default.
• W2115059097 hasBestOaLocation W21150590971 @default.
• W2115059097 hasConcept C102230213 @default.
• W2115059097 hasConcept C104317684 @default.
• W2115059097 hasConcept C108204754 @default.
• W2115059097 hasConcept C114246631 @default.
• W2115059097 hasConcept C143065580 @default.
• W2115059097 hasConcept C153911025 @default.
• W2115059097 hasConcept C16318435 @default.
• W2115059097 hasConcept C178790620 @default.
• W2115059097 hasConcept C185592680 @default.
• W2115059097 hasConcept C207001950 @default.
• W2115059097 hasConcept C2776639595 @default.
• W2115059097 hasConcept C2777538855 @default.
• W2115059097 hasConcept C2778951431 @default.
• W2115059097 hasConcept C29730261 @default.
• W2115059097 hasConcept C54355233 @default.
• W2115059097 hasConcept C552990157 @default.
• W2115059097 hasConcept C55493867 @default.
• W2115059097 hasConcept C86803240 @default.
• W2115059097 hasConcept C98274493 @default.
• W2115059097 hasConceptScore W2115059097C102230213 @default.
• W2115059097 hasConceptScore W2115059097C104317684 @default.
• W2115059097 hasConceptScore W2115059097C108204754 @default.
• W2115059097 hasConceptScore W2115059097C114246631 @default.
• W2115059097 hasConceptScore W2115059097C143065580 @default.
• W2115059097 hasConceptScore W2115059097C153911025 @default.
• W2115059097 hasConceptScore W2115059097C16318435 @default.
• W2115059097 hasConceptScore W2115059097C178790620 @default.
• W2115059097 hasConceptScore W2115059097C185592680 @default.
• W2115059097 hasConceptScore W2115059097C207001950 @default.
• W2115059097 hasConceptScore W2115059097C2776639595 @default.
• W2115059097 hasConceptScore W2115059097C2777538855 @default.
• W2115059097 hasConceptScore W2115059097C2778951431 @default.
• W2115059097 hasConceptScore W2115059097C29730261 @default.
• W2115059097 hasConceptScore W2115059097C54355233 @default.
• W2115059097 hasConceptScore W2115059097C552990157 @default.
• W2115059097 hasConceptScore W2115059097C55493867 @default.
• W2115059097 hasConceptScore W2115059097C86803240 @default.
• W2115059097 hasConceptScore W2115059097C98274493 @default.
• W2115059097 hasIssue "6" @default.

• next