FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115059455> ?p ?o ?g. }

• W2115059455 endingPage "2484" @default.
• W2115059455 startingPage "2475" @default.
• W2115059455 abstract "BackgroundThe granulocyte colony-stimulating factor (G-CSF) is utilized to reduce neutropenic complications in patients receiving cancer chemotherapy. This study represents a systematic review and evidence summary of the impact of G-CSF support on chemotherapy dose intensity and overall mortality.Materials and methodsAll randomized controlled trials (RCTs) comparing chemotherapy with or without G-CSF support and reporting all-cause mortality with at least 2 years of follow-up were sought. Dual-blind data abstraction of disease, treatment, patient and outcome study results with conflict resolution by third party was carried out.ResultsThe search revealed 61 randomized comparisons of chemotherapy with or without initial G-CSF support. Death was reported in 4251 patients randomized to G-CSFs and in 5188 controls. Relative risk (RR) with G-CSF support for all-cause mortality was 0.93 (95% confidence interval: 0.90–0.96; P < 0.001). RR for mortality varied by intended chemotherapy dose and schedule: same dose and schedule (RR = 0.96; P = 0.060), dose dense (RR = 0.89; P < 0.001), dose escalation (RR = 0.92; P = 0.019) and drug substitution or addition (RR = 0.94; P = 0.003). Greater RR reduction was observed among studies with longer follow-up (P = 0.02), where treatment was for curative intent (RR = 0.91; P < 0.001), and where survival was the primary outcome (RR = 0.91; P < 0.001).ConclusionsAll-cause mortality is reduced in patients receiving chemotherapy with primary G-CSF support. The greatest impact was observed in RCTs in patients receiving dose-dense schedules." @default.
• W2115059455 created "2016-06-24" @default.
• W2115059455 creator A5015520404 @default.
• W2115059455 creator A5020077779 @default.
• W2115059455 creator A5030514163 @default.
• W2115059455 creator A5037771704 @default.
• W2115059455 creator A5062529227 @default.
• W2115059455 creator A5073060840 @default.
• W2115059455 creator A5089115491 @default.
• W2115059455 creator A5090143035 @default.
• W2115059455 date "2013-10-01" @default.
• W2115059455 modified "2023-09-29" @default.
• W2115059455 title "The impact of the granulocyte colony-stimulating factor on chemotherapy dose intensity and cancer survival: a systematic review and meta-analysis of randomized controlled trials" @default.
• W2115059455 cites W1868450210 @default.
• W2115059455 cites W1964435302 @default.
• W2115059455 cites W2000253139 @default.
• W2115059455 cites W2024933507 @default.
• W2115059455 cites W2025689023 @default.
• W2115059455 cites W2029374110 @default.
• W2115059455 cites W2036740 @default.
• W2115059455 cites W2059070026 @default.
• W2115059455 cites W2062236242 @default.
• W2115059455 cites W2077421021 @default.
• W2115059455 cites W2083725441 @default.
• W2115059455 cites W2095645261 @default.
• W2115059455 cites W2099562503 @default.
• W2115059455 cites W2108465006 @default.
• W2115059455 cites W2112787148 @default.
• W2115059455 cites W2125435699 @default.
• W2115059455 cites W2135800076 @default.
• W2115059455 cites W2136962826 @default.
• W2115059455 cites W2142195688 @default.
• W2115059455 cites W2157823046 @default.
• W2115059455 cites W2166572860 @default.
• W2115059455 cites W2225863772 @default.
• W2115059455 cites W4238449855 @default.
• W2115059455 doi "https://doi.org/10.1093/annonc/mdt226" @default.
• W2115059455 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3841419" @default.
• W2115059455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23788754" @default.
• W2115059455 hasPublicationYear "2013" @default.
• W2115059455 type Work @default.
• W2115059455 sameAs 2115059455 @default.
• W2115059455 citedByCount "155" @default.
• W2115059455 countsByYear W21150594552014 @default.
• W2115059455 countsByYear W21150594552015 @default.
• W2115059455 countsByYear W21150594552016 @default.
• W2115059455 countsByYear W21150594552017 @default.
• W2115059455 countsByYear W21150594552018 @default.
• W2115059455 countsByYear W21150594552019 @default.
• W2115059455 countsByYear W21150594552020 @default.
• W2115059455 countsByYear W21150594552021 @default.
• W2115059455 countsByYear W21150594552022 @default.
• W2115059455 countsByYear W21150594552023 @default.
• W2115059455 crossrefType "journal-article" @default.
• W2115059455 hasAuthorship W2115059455A5015520404 @default.
• W2115059455 hasAuthorship W2115059455A5020077779 @default.
• W2115059455 hasAuthorship W2115059455A5030514163 @default.
• W2115059455 hasAuthorship W2115059455A5037771704 @default.
• W2115059455 hasAuthorship W2115059455A5062529227 @default.
• W2115059455 hasAuthorship W2115059455A5073060840 @default.
• W2115059455 hasAuthorship W2115059455A5089115491 @default.
• W2115059455 hasAuthorship W2115059455A5090143035 @default.
• W2115059455 hasBestOaLocation W21150594551 @default.
• W2115059455 hasConcept C126322002 @default.
• W2115059455 hasConcept C141071460 @default.
• W2115059455 hasConcept C143998085 @default.
• W2115059455 hasConcept C168563851 @default.
• W2115059455 hasConcept C2776694085 @default.
• W2115059455 hasConcept C2777767877 @default.
• W2115059455 hasConcept C44249647 @default.
• W2115059455 hasConcept C71924100 @default.
• W2115059455 hasConcept C82789193 @default.
• W2115059455 hasConceptScore W2115059455C126322002 @default.
• W2115059455 hasConceptScore W2115059455C141071460 @default.
• W2115059455 hasConceptScore W2115059455C143998085 @default.
• W2115059455 hasConceptScore W2115059455C168563851 @default.
• W2115059455 hasConceptScore W2115059455C2776694085 @default.
• W2115059455 hasConceptScore W2115059455C2777767877 @default.
• W2115059455 hasConceptScore W2115059455C44249647 @default.
• W2115059455 hasConceptScore W2115059455C71924100 @default.
• W2115059455 hasConceptScore W2115059455C82789193 @default.
• W2115059455 hasIssue "10" @default.
• W2115059455 hasLocation W21150594551 @default.
• W2115059455 hasLocation W21150594552 @default.
• W2115059455 hasLocation W21150594553 @default.
• W2115059455 hasLocation W21150594554 @default.
• W2115059455 hasOpenAccess W2115059455 @default.
• W2115059455 hasPrimaryLocation W21150594551 @default.
• W2115059455 hasRelatedWork W1898692666 @default.
• W2115059455 hasRelatedWork W1992798646 @default.
• W2115059455 hasRelatedWork W2003563983 @default.
• W2115059455 hasRelatedWork W2094278111 @default.
• W2115059455 hasRelatedWork W2235155022 @default.
• W2115059455 hasRelatedWork W2598584487 @default.
• W2115059455 hasRelatedWork W2775018271 @default.
• W2115059455 hasRelatedWork W2808786485 @default.
• W2115059455 hasRelatedWork W3030276453 @default.
• W2115059455 hasRelatedWork W3117712864 @default.

• next