Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115068632> ?p ?o ?g. }
- W2115068632 endingPage "9" @default.
- W2115068632 startingPage "141" @default.
- W2115068632 abstract "The hydroxymethylglutaryl-CoA reductase inhibitor lovastatin is used widely to treat hypercholesterolemia and has been shown to have cell cycle-specific effects. In these studies, we have examined the effects of combining lovastatin and paclitaxel (Taxol), a microtubule-stabilizing agent, in the human leukemia K562 and HL-60 cell lines. Isobologram analysis of cytotoxicity assays revealed that there is a synergistic interaction between the two agents in both cell lines. Cell cycle analyses showed that lovastatin enhances paclitaxel-induced G2-M arrest in both cell lines. In addition, Annexin V apoptotic studies revealed that lovastatin enhances paclitaxel-induced apoptosis in HL-60 cells. Lovastatin did not affect levels of [3H]paclitaxel in cells. Whereas lovastatin induced an accumulation of unmodified Ras and caused an up-regulation of both RhoB and Rap1A, paclitaxel was found to have no effect on the isoprenylated proteins. Studies of the centromere-associated protein mitosin revealed that treatment with lovastatin and paclitaxel resulted in increased mitosin levels and that lovastatin altered the association of mitosin with condensed chromosomes. These findings provide insight into the mechanisms underlying the cell cycle effects of lovastatin and support the development of a novel therapeutic strategy directed toward altering deleterious cell proliferation." @default.
- W2115068632 created "2016-06-24" @default.
- W2115068632 creator A5005732386 @default.
- W2115068632 creator A5051858382 @default.
- W2115068632 date "2001-12-01" @default.
- W2115068632 modified "2023-09-23" @default.
- W2115068632 title "Synergistic interaction of lovastatin and paclitaxel in human cancer cells." @default.
- W2115068632 cites W1003977362 @default.
- W2115068632 cites W130020229 @default.
- W2115068632 cites W1491433568 @default.
- W2115068632 cites W1502312403 @default.
- W2115068632 cites W1517546728 @default.
- W2115068632 cites W1540158309 @default.
- W2115068632 cites W1541625068 @default.
- W2115068632 cites W1616592835 @default.
- W2115068632 cites W172339184 @default.
- W2115068632 cites W1775749144 @default.
- W2115068632 cites W1905736667 @default.
- W2115068632 cites W1911989431 @default.
- W2115068632 cites W1914283638 @default.
- W2115068632 cites W1968028322 @default.
- W2115068632 cites W1968758492 @default.
- W2115068632 cites W1976033985 @default.
- W2115068632 cites W1985753931 @default.
- W2115068632 cites W1999098901 @default.
- W2115068632 cites W2004191401 @default.
- W2115068632 cites W2004855758 @default.
- W2115068632 cites W2016678257 @default.
- W2115068632 cites W2024462254 @default.
- W2115068632 cites W2036385909 @default.
- W2115068632 cites W2036699032 @default.
- W2115068632 cites W2071124826 @default.
- W2115068632 cites W2072800048 @default.
- W2115068632 cites W2076578505 @default.
- W2115068632 cites W2077945404 @default.
- W2115068632 cites W2078603028 @default.
- W2115068632 cites W2081406767 @default.
- W2115068632 cites W2087328245 @default.
- W2115068632 cites W2089906643 @default.
- W2115068632 cites W2100147739 @default.
- W2115068632 cites W2106405240 @default.
- W2115068632 cites W2107424534 @default.
- W2115068632 cites W2116906268 @default.
- W2115068632 cites W2117046467 @default.
- W2115068632 cites W2133709362 @default.
- W2115068632 cites W2145978772 @default.
- W2115068632 cites W2165982968 @default.
- W2115068632 cites W2166291746 @default.
- W2115068632 cites W2168852008 @default.
- W2115068632 cites W2170912376 @default.
- W2115068632 cites W2186847038 @default.
- W2115068632 cites W2249096125 @default.
- W2115068632 cites W2284708139 @default.
- W2115068632 cites W2402402931 @default.
- W2115068632 cites W2411247746 @default.
- W2115068632 cites W3113125785 @default.
- W2115068632 cites W57954726 @default.
- W2115068632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12467231" @default.
- W2115068632 hasPublicationYear "2001" @default.
- W2115068632 type Work @default.
- W2115068632 sameAs 2115068632 @default.
- W2115068632 citedByCount "26" @default.
- W2115068632 countsByYear W21150686322012 @default.
- W2115068632 countsByYear W21150686322013 @default.
- W2115068632 countsByYear W21150686322014 @default.
- W2115068632 countsByYear W21150686322015 @default.
- W2115068632 countsByYear W21150686322016 @default.
- W2115068632 countsByYear W21150686322017 @default.
- W2115068632 countsByYear W21150686322018 @default.
- W2115068632 countsByYear W21150686322019 @default.
- W2115068632 countsByYear W21150686322022 @default.
- W2115068632 crossrefType "journal-article" @default.
- W2115068632 hasAuthorship W2115068632A5005732386 @default.
- W2115068632 hasAuthorship W2115068632A5051858382 @default.
- W2115068632 hasConcept C104950815 @default.
- W2115068632 hasConcept C105696609 @default.
- W2115068632 hasConcept C109316439 @default.
- W2115068632 hasConcept C121608353 @default.
- W2115068632 hasConcept C134651460 @default.
- W2115068632 hasConcept C181199279 @default.
- W2115068632 hasConcept C185592680 @default.
- W2115068632 hasConcept C190283241 @default.
- W2115068632 hasConcept C202751555 @default.
- W2115068632 hasConcept C2777292972 @default.
- W2115068632 hasConcept C2778163477 @default.
- W2115068632 hasConcept C2780940807 @default.
- W2115068632 hasConcept C29537977 @default.
- W2115068632 hasConcept C502942594 @default.
- W2115068632 hasConcept C54355233 @default.
- W2115068632 hasConcept C55493867 @default.
- W2115068632 hasConcept C62112901 @default.
- W2115068632 hasConcept C81885089 @default.
- W2115068632 hasConcept C86803240 @default.
- W2115068632 hasConcept C98274493 @default.
- W2115068632 hasConceptScore W2115068632C104950815 @default.
- W2115068632 hasConceptScore W2115068632C105696609 @default.
- W2115068632 hasConceptScore W2115068632C109316439 @default.
- W2115068632 hasConceptScore W2115068632C121608353 @default.