FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115072813> ?p ?o ?g. }

• W2115072813 endingPage "1538" @default.
• W2115072813 startingPage "1529" @default.
• W2115072813 abstract "The Suppressor of forked protein is the Drosophila homolog of the 77K subunit of human cleavage stimulation factor, a complex required for the first step of the mRNA 3'-end-processing reaction. We have shown previously that wild-type su(f) function is required for the accumulation of a truncated su(f) transcript polyadenylated in intron 4 of the gene. This led us to propose a model in which the Su(f) protein would negatively regulate its own accumulation by stimulating 3'-end formation of this truncated su(f) RNA. In this article, we demonstrate this model and show that su(f) autoregulation is tissue specific. The Su(f) protein accumulates at a high level in dividing tissues, but not in nondividing tissues. We show that this distribution of the Su(f) protein results from stimulation by Su(f) of the tissue-specific utilization of the su(f) intronic poly(A) site, leading to the accumulation of the truncated su(f) transcript in nondividing tissues. Utilization of this intronic poly(A) site is affected in a su(f) mutant and restored in the mutant with a transgene encoding wild-type Su(f) protein. These data provide an in vivo example of cell-type-specific regulation of a protein level by poly(A) site choice, and confirm the role of Su(f) in regulation of poly(A) site utilization." @default.
• W2115072813 created "2016-06-24" @default.
• W2115072813 creator A5000972082 @default.
• W2115072813 creator A5024305684 @default.
• W2115072813 creator A5056473784 @default.
• W2115072813 creator A5067225986 @default.
• W2115072813 date "2000-11-01" @default.
• W2115072813 modified "2023-10-13" @default.
• W2115072813 title "Tissue-specific autoregulation of Drosophila suppressor of forked by alternative poly(A) site utilization leads to accumulation of the suppressor of forked protein in mitotically active cells" @default.
• W2115072813 cites W1875884436 @default.
• W2115072813 cites W1918735662 @default.
• W2115072813 cites W1972208485 @default.
• W2115072813 cites W1994528729 @default.
• W2115072813 cites W1995824852 @default.
• W2115072813 cites W1996137451 @default.
• W2115072813 cites W2000518294 @default.
• W2115072813 cites W2005764753 @default.
• W2115072813 cites W2011985459 @default.
• W2115072813 cites W2012569825 @default.
• W2115072813 cites W2027784918 @default.
• W2115072813 cites W2038299113 @default.
• W2115072813 cites W2040386515 @default.
• W2115072813 cites W2054084236 @default.
• W2115072813 cites W2055965639 @default.
• W2115072813 cites W2079932405 @default.
• W2115072813 cites W2089732199 @default.
• W2115072813 cites W2091429016 @default.
• W2115072813 cites W2094712225 @default.
• W2115072813 cites W2095915699 @default.
• W2115072813 cites W2096085195 @default.
• W2115072813 cites W2110643873 @default.
• W2115072813 cites W2110946097 @default.
• W2115072813 cites W2114476704 @default.
• W2115072813 cites W2120610548 @default.
• W2115072813 cites W2123818790 @default.
• W2115072813 cites W2128407129 @default.
• W2115072813 cites W2129136527 @default.
• W2115072813 cites W2151971476 @default.
• W2115072813 cites W2154272601 @default.
• W2115072813 cites W2159666069 @default.
• W2115072813 cites W2186621177 @default.
• W2115072813 cites W55933576 @default.
• W2115072813 cites W2007980918 @default.
• W2115072813 doi "https://doi.org/10.1017/s1355838200001266" @default.
• W2115072813 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1370023" @default.
• W2115072813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11105753" @default.
• W2115072813 hasPublicationYear "2000" @default.
• W2115072813 type Work @default.
• W2115072813 sameAs 2115072813 @default.
• W2115072813 citedByCount "23" @default.
• W2115072813 countsByYear W21150728132012 @default.
• W2115072813 countsByYear W21150728132013 @default.
• W2115072813 countsByYear W21150728132014 @default.
• W2115072813 countsByYear W21150728132021 @default.
• W2115072813 crossrefType "journal-article" @default.
• W2115072813 hasAuthorship W2115072813A5000972082 @default.
• W2115072813 hasAuthorship W2115072813A5024305684 @default.
• W2115072813 hasAuthorship W2115072813A5056473784 @default.
• W2115072813 hasAuthorship W2115072813A5067225986 @default.
• W2115072813 hasBestOaLocation W21150728132 @default.
• W2115072813 hasConcept C104292427 @default.
• W2115072813 hasConcept C104317684 @default.
• W2115072813 hasConcept C105580179 @default.
• W2115072813 hasConcept C142575336 @default.
• W2115072813 hasConcept C143065580 @default.
• W2115072813 hasConcept C153911025 @default.
• W2115072813 hasConcept C173396325 @default.
• W2115072813 hasConcept C179185449 @default.
• W2115072813 hasConcept C207583985 @default.
• W2115072813 hasConcept C55493867 @default.
• W2115072813 hasConcept C67492840 @default.
• W2115072813 hasConcept C67705224 @default.
• W2115072813 hasConcept C86803240 @default.
• W2115072813 hasConcept C94671646 @default.
• W2115072813 hasConcept C95444343 @default.
• W2115072813 hasConceptScore W2115072813C104292427 @default.
• W2115072813 hasConceptScore W2115072813C104317684 @default.
• W2115072813 hasConceptScore W2115072813C105580179 @default.
• W2115072813 hasConceptScore W2115072813C142575336 @default.
• W2115072813 hasConceptScore W2115072813C143065580 @default.
• W2115072813 hasConceptScore W2115072813C153911025 @default.
• W2115072813 hasConceptScore W2115072813C173396325 @default.
• W2115072813 hasConceptScore W2115072813C179185449 @default.
• W2115072813 hasConceptScore W2115072813C207583985 @default.
• W2115072813 hasConceptScore W2115072813C55493867 @default.
• W2115072813 hasConceptScore W2115072813C67492840 @default.
• W2115072813 hasConceptScore W2115072813C67705224 @default.
• W2115072813 hasConceptScore W2115072813C86803240 @default.
• W2115072813 hasConceptScore W2115072813C94671646 @default.
• W2115072813 hasConceptScore W2115072813C95444343 @default.
• W2115072813 hasIssue "11" @default.
• W2115072813 hasLocation W21150728131 @default.
• W2115072813 hasLocation W21150728132 @default.
• W2115072813 hasLocation W21150728133 @default.
• W2115072813 hasLocation W21150728134 @default.
• W2115072813 hasOpenAccess W2115072813 @default.
• W2115072813 hasPrimaryLocation W21150728131 @default.
• W2115072813 hasRelatedWork W1488258440 @default.

• next