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- W2115078615 abstract "The purpose of this study was to develop a noninvasive imaging test of pancreatic exocrine function. <b>Methods:</b> In this pilot study, 5 healthy volunteers underwent two 60-min dynamic <sup>11</sup>C-acetate PET studies, one before and one after intravenous secretin administration. Kinetic analysis of the pancreas was performed using a 1-compartment model and an image-derived input function. From summed images, standardized uptake values were measured from the pancreas and the liver, and the pancreas-to-liver ratio was computed. <b>Results:</b> The baseline <i>k</i><sub>1</sub> and <i>k</i><sub>2</sub> data for all 5 volunteers were consistent. After secretin stimulation, the <i>k</i><sub>1</sub> and <i>k</i><sub>2</sub> significantly increased (paired <i>t</i> test <i>P</i> = 0.046 and <i>P</i> = 0.023, respectively). In the summed PET images, the pancreas-to-liver ratio decreased (<i>P</i> = 0.037). Increased <sup>11</sup>C-acetate activity was observed in the duodenum after secretin stimulation consistent with secretin-induced secretion. <b>Conclusion:</b><sup>11</sup>C-acetate PET studies with secretin stimulation show potential as a noninvasive method for assessing pancreatic exocrine function." @default.
- W2115078615 created "2016-06-24" @default.
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- W2115078615 date "2014-05-19" @default.
- W2115078615 modified "2023-09-25" @default.
- W2115078615 title "An Exocrine Pancreatic Stress Test with <sup>11</sup>C-Acetate PET and Secretin Stimulation" @default.
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- W2115078615 doi "https://doi.org/10.2967/jnumed.113.135681" @default.
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