FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115080052> ?p ?o ?g. }

• W2115080052 endingPage "1566" @default.
• W2115080052 startingPage "1556" @default.
• W2115080052 abstract "Several factors are thought to be implicated in the occurrence of idiosyncratic adverse drug reactions. The present work aimed to question as to whether inflammation is a determinant factor in hepatic lesions induced by chlorpromazine (CPZ) using the human HepaRG cell line. An inflammation state was induced by a 24-hour exposure to proinflammatory cytokines interleukin-6 (IL-6) and IL-1β; then the cells were simultaneously treated with CPZ and/or cytokine for 24 hours or daily for 5 days. The inflammatory response was assessed by induction of C-reactive protein and IL-8 transcripts and proteins as well as inhibition of CPZ metabolism and down-regulation of cytochrome 3A4 (CYP3A4) and CYP1A2 transcripts, two major cytochrome P450 (P450) enzymes involved in its metabolism. Most effects of cotreatments with cytokines and CPZ were amplified or only observed after five daily treatments; they mainly included increased cytotoxicity and overexpression of oxidative stress-related genes, decreased Na(+)-taurocholate cotransporting polypeptide mRNA levels and activity, a key transporter involved in bile acids uptake, and deregulation of several other transporters. However, CPZ-induced inhibition of taurocholic acid efflux and pericanalicular F-actin distribution were not affected. In addition, a time-dependent induction of phospholipidosis was noticed in CPZ-treated cells, without obvious influence of the inflammatory stress. In summary, our results show that an inflammatory state induced by proinflammatory cytokines increased cytotoxicity and enhanced some cholestatic features induced by the idiosyncratic drug CPZ in HepaRG cells. These changes, together with inhibition of P450 activities, could have important consequences if extrapolated to the in vivo situation." @default.
• W2115080052 created "2016-06-24" @default.
• W2115080052 creator A5001061041 @default.
• W2115080052 creator A5004029396 @default.
• W2115080052 creator A5021796710 @default.
• W2115080052 creator A5036286276 @default.
• W2115080052 creator A5042549211 @default.
• W2115080052 creator A5054209424 @default.
• W2115080052 creator A5058587451 @default.
• W2115080052 creator A5071754418 @default.
• W2115080052 creator A5072867071 @default.
• W2115080052 creator A5079470105 @default.
• W2115080052 creator A5089694873 @default.
• W2115080052 date "2014-07-07" @default.
• W2115080052 modified "2023-10-15" @default.
• W2115080052 title "Impact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG Cells" @default.
• W2115080052 cites W1531820670 @default.
• W2115080052 cites W1822042631 @default.
• W2115080052 cites W1965635980 @default.
• W2115080052 cites W1966514588 @default.
• W2115080052 cites W1980455299 @default.
• W2115080052 cites W1980944102 @default.
• W2115080052 cites W1983060510 @default.
• W2115080052 cites W1993015516 @default.
• W2115080052 cites W1994912901 @default.
• W2115080052 cites W2019955239 @default.
• W2115080052 cites W2021878099 @default.
• W2115080052 cites W2030790584 @default.
• W2115080052 cites W2031802816 @default.
• W2115080052 cites W2032758907 @default.
• W2115080052 cites W2035059384 @default.
• W2115080052 cites W2037140424 @default.
• W2115080052 cites W2044634578 @default.
• W2115080052 cites W2060261844 @default.
• W2115080052 cites W2069003463 @default.
• W2115080052 cites W2074240508 @default.
• W2115080052 cites W2077692978 @default.
• W2115080052 cites W2082784116 @default.
• W2115080052 cites W2083811181 @default.
• W2115080052 cites W2088160623 @default.
• W2115080052 cites W2094392052 @default.
• W2115080052 cites W2095481879 @default.
• W2115080052 cites W2107790148 @default.
• W2115080052 cites W2119236309 @default.
• W2115080052 cites W2120426460 @default.
• W2115080052 cites W2139618526 @default.
• W2115080052 cites W2151875144 @default.
• W2115080052 cites W2152986929 @default.
• W2115080052 cites W2159562550 @default.
• W2115080052 cites W2159632264 @default.
• W2115080052 cites W2168343307 @default.
• W2115080052 cites W2169025971 @default.
• W2115080052 doi "https://doi.org/10.1124/dmd.114.058123" @default.
• W2115080052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25002748" @default.
• W2115080052 hasPublicationYear "2014" @default.
• W2115080052 type Work @default.
• W2115080052 sameAs 2115080052 @default.
• W2115080052 citedByCount "24" @default.
• W2115080052 countsByYear W21150800522014 @default.
• W2115080052 countsByYear W21150800522015 @default.
• W2115080052 countsByYear W21150800522016 @default.
• W2115080052 countsByYear W21150800522017 @default.
• W2115080052 countsByYear W21150800522018 @default.
• W2115080052 countsByYear W21150800522019 @default.
• W2115080052 countsByYear W21150800522020 @default.
• W2115080052 countsByYear W21150800522022 @default.
• W2115080052 countsByYear W21150800522023 @default.
• W2115080052 crossrefType "journal-article" @default.
• W2115080052 hasAuthorship W2115080052A5001061041 @default.
• W2115080052 hasAuthorship W2115080052A5004029396 @default.
• W2115080052 hasAuthorship W2115080052A5021796710 @default.
• W2115080052 hasAuthorship W2115080052A5036286276 @default.
• W2115080052 hasAuthorship W2115080052A5042549211 @default.
• W2115080052 hasAuthorship W2115080052A5054209424 @default.
• W2115080052 hasAuthorship W2115080052A5058587451 @default.
• W2115080052 hasAuthorship W2115080052A5071754418 @default.
• W2115080052 hasAuthorship W2115080052A5072867071 @default.
• W2115080052 hasAuthorship W2115080052A5079470105 @default.
• W2115080052 hasAuthorship W2115080052A5089694873 @default.
• W2115080052 hasConcept C104317684 @default.
• W2115080052 hasConcept C109316439 @default.
• W2115080052 hasConcept C109650736 @default.
• W2115080052 hasConcept C149011108 @default.
• W2115080052 hasConcept C164027704 @default.
• W2115080052 hasConcept C185592680 @default.
• W2115080052 hasConcept C202751555 @default.
• W2115080052 hasConcept C203014093 @default.
• W2115080052 hasConcept C2776914184 @default.
• W2115080052 hasConcept C2778690821 @default.
• W2115080052 hasConcept C2778918659 @default.
• W2115080052 hasConcept C2779934242 @default.
• W2115080052 hasConcept C41625074 @default.
• W2115080052 hasConcept C526171541 @default.
• W2115080052 hasConcept C55493867 @default.
• W2115080052 hasConcept C62231903 @default.
• W2115080052 hasConcept C86745063 @default.
• W2115080052 hasConcept C86803240 @default.
• W2115080052 hasConcept C98274493 @default.

• next