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• W2115086302 abstract "This study evaluated the relative bioavailability of a sustained-release capsule of theophylline, an elixir of theophylline, and a sustained-release tablet of aminophylline. Twelve healthy, nonsmoking, adult male subjects received nine doses of each of the three products in a crossover study conducted over a ten-day period. Each dosage form contained approximately 250 mg of theophylline and was administered every eight hours. Concentrations of theophylline in the plasma at steady state demonstrated the equivalence of the three dosage forms in terms of the percent of drug absorbed, including the tablet which had exhibited reduced bioavailability in an earlier single-dose study of only five subjects. The steady-state average concentrations of theophylline in the plasma were 9.8 µg/ml, 10.3 µg/ml and 10.8 µg/ml for the tablet, capsule, and elixir, respectively. The areas under the curves of the plasma level vs time for the three dosage forms were within 9 percent of each other. These data indicate that a significant reduction in fluctuations of the plasma level of theophylline was achieved with the two sustained-release dosage forms, compared to the elixir. This study evaluated the relative bioavailability of a sustained-release capsule of theophylline, an elixir of theophylline, and a sustained-release tablet of aminophylline. Twelve healthy, nonsmoking, adult male subjects received nine doses of each of the three products in a crossover study conducted over a ten-day period. Each dosage form contained approximately 250 mg of theophylline and was administered every eight hours. Concentrations of theophylline in the plasma at steady state demonstrated the equivalence of the three dosage forms in terms of the percent of drug absorbed, including the tablet which had exhibited reduced bioavailability in an earlier single-dose study of only five subjects. The steady-state average concentrations of theophylline in the plasma were 9.8 µg/ml, 10.3 µg/ml and 10.8 µg/ml for the tablet, capsule, and elixir, respectively. The areas under the curves of the plasma level vs time for the three dosage forms were within 9 percent of each other. These data indicate that a significant reduction in fluctuations of the plasma level of theophylline was achieved with the two sustained-release dosage forms, compared to the elixir. Controlled Release TheophyllineCHESTVol. 78Issue 2PreviewIt is generally accepted that the therapeutic activity of theophylline in patients with reversible airway disease can be maximized by maintaining the plasma concentration above 10 µg/ml. The dosage form of theophylline can influence rate and extent of drug delivery and therefore can influence the plasma level. In this issue of Chest (see page 300) Meyer and co-workers reported on the bioavailability of three different theophylline or aminophylline dosage forms manufactured by one pharmaceutical company. Full-Text PDF" @default.
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• W2115086302 date "1980-08-01" @default.
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• W2115086302 title "A Multiple-Dose Study of Sustained-Release Theophylline and Aminophylline" @default.
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• W2115086302 doi "https://doi.org/10.1378/chest.78.2.300" @default.
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