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- W2115087100 abstract "Abstract Glial cell line‐derived neurotrophic factor (GDNF) promotes the survival and functions of neurons. It has been shown to be a promising candidate in the treatment of ischemia and other neurodegenerative diseases. We transfected mouse astrocytes in primary cultures with a human GDNF gene and found that their conditioned medium could not only support the growth and survival of cultured dopaminergic neurons but also protect astrocytes from staurosporine‐ and ischemia‐induced apoptosis. This indicated that these transfected astrocytes could release GDNF. A similar protective effect on astrocytes against apoptosis was evident when recombinant human GDNF was used. Moreover, GDNF reduced caspase‐3 activity but not that of caspase‐1 in cultured astrocytes after ischemia treatment. Thus, GDNF protects astrocytes from apoptosis by inhibiting the activation of caspase‐3. © 2007 Wiley‐Liss, Inc." @default.
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- W2115087100 date "2007-05-11" @default.
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- W2115087100 title "Glial cell line-derived neurotrophic factor protects astrocytes from staurosporine- and ischemia- induced apoptosis" @default.
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- W2115087100 doi "https://doi.org/10.1002/jnr.21345" @default.
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