Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115087258> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2115087258 endingPage "450" @default.
- W2115087258 startingPage "446" @default.
- W2115087258 abstract "The 4th EMBO Workshop on Nuclear Organization took place between 12 and 15 October 2006 in Gosau, Austria, and was organized by D. Jackson, R. van Driel, H. Lipps and H. Westerhoff.![][1] It is clear that DNA sequence and transcription factor availability alone are not sufficient for effective gene regulation in eukaryotes. Epigenetic factors at various levels also have an essential role: for example, DNA methylation and histone modifications form the molecular basis of gene regulation by creating chromatin microenvironments that promote or prevent transcription. Gene activation requires complete cascades of chromatin modifiers to prepare the chromatin for transcription. In addition, the topology of the chromatin and the dynamic interactions between nuclear bodies influence genome function. How the appropriate and controlled expression of genes is achieved is clearly a complicated system, both in terms of the number of interacting components and the spatial heterogeneity. In other areas of cell function that are carried out by multi‐enzyme networks, the question of how function arises from the interaction of the relevant components is being addressed by various combined theoretical and experimental approaches termed ‘systems biology’. Such an approach could determine the extent to which known interactions explain chromatin function and identify what remains to be understood. Furthermore, the combination of mathematical and computational modelling with quantitative measurements fulfils an urgent requirement, as it has the rigour to derive robust predictions that can be precisely tested against experimental observations to support or disprove hypotheses. This meeting brought together experts in chromatin function and systems biology to inform each other of the approaches and issues in their respective fields, and to explore whether they are ready to interact to develop the systems biology of chromatin function. Inevitably, few of the participants could claim to span both fields, but the two opening plenary talks by … [1]: /embed/graphic-1.gif" @default.
- W2115087258 created "2016-06-24" @default.
- W2115087258 creator A5019780955 @default.
- W2115087258 creator A5030588495 @default.
- W2115087258 date "2007-04-13" @default.
- W2115087258 modified "2023-10-16" @default.
- W2115087258 title "Systems biology meets chromatin function" @default.
- W2115087258 cites W1974862758 @default.
- W2115087258 cites W1975351609 @default.
- W2115087258 cites W2002583673 @default.
- W2115087258 cites W2022521591 @default.
- W2115087258 cites W2032464841 @default.
- W2115087258 cites W2037187863 @default.
- W2115087258 cites W2058681208 @default.
- W2115087258 doi "https://doi.org/10.1038/sj.embor.7400960" @default.
- W2115087258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1866206" @default.
- W2115087258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17431407" @default.
- W2115087258 hasPublicationYear "2007" @default.
- W2115087258 type Work @default.
- W2115087258 sameAs 2115087258 @default.
- W2115087258 citedByCount "2" @default.
- W2115087258 crossrefType "journal-article" @default.
- W2115087258 hasAuthorship W2115087258A5019780955 @default.
- W2115087258 hasAuthorship W2115087258A5030588495 @default.
- W2115087258 hasBestOaLocation W21150872582 @default.
- W2115087258 hasConcept C14036430 @default.
- W2115087258 hasConcept C152662350 @default.
- W2115087258 hasConcept C41008148 @default.
- W2115087258 hasConcept C54355233 @default.
- W2115087258 hasConcept C552990157 @default.
- W2115087258 hasConcept C70721500 @default.
- W2115087258 hasConcept C83640560 @default.
- W2115087258 hasConcept C86803240 @default.
- W2115087258 hasConcept C95444343 @default.
- W2115087258 hasConceptScore W2115087258C14036430 @default.
- W2115087258 hasConceptScore W2115087258C152662350 @default.
- W2115087258 hasConceptScore W2115087258C41008148 @default.
- W2115087258 hasConceptScore W2115087258C54355233 @default.
- W2115087258 hasConceptScore W2115087258C552990157 @default.
- W2115087258 hasConceptScore W2115087258C70721500 @default.
- W2115087258 hasConceptScore W2115087258C83640560 @default.
- W2115087258 hasConceptScore W2115087258C86803240 @default.
- W2115087258 hasConceptScore W2115087258C95444343 @default.
- W2115087258 hasIssue "5" @default.
- W2115087258 hasLocation W21150872581 @default.
- W2115087258 hasLocation W21150872582 @default.
- W2115087258 hasLocation W21150872583 @default.
- W2115087258 hasLocation W21150872584 @default.
- W2115087258 hasOpenAccess W2115087258 @default.
- W2115087258 hasPrimaryLocation W21150872581 @default.
- W2115087258 hasRelatedWork W1828691184 @default.
- W2115087258 hasRelatedWork W2002128513 @default.
- W2115087258 hasRelatedWork W2013095276 @default.
- W2115087258 hasRelatedWork W2036519228 @default.
- W2115087258 hasRelatedWork W2056182651 @default.
- W2115087258 hasRelatedWork W2086568203 @default.
- W2115087258 hasRelatedWork W2115260093 @default.
- W2115087258 hasRelatedWork W3004515236 @default.
- W2115087258 hasRelatedWork W3212874355 @default.
- W2115087258 hasRelatedWork W2092874662 @default.
- W2115087258 hasVolume "8" @default.
- W2115087258 isParatext "false" @default.
- W2115087258 isRetracted "false" @default.
- W2115087258 magId "2115087258" @default.
- W2115087258 workType "article" @default.
!["The 4th EMBO Workshop on Nuclear Organization took place between 12 and 15 October 2006 in Gosau, Austria, and was organized by D. Jackson, R. van Driel, H. Lipps and H. Westerhoff.![][1] It is clear that DNA sequence and transcription factor availability alone are not sufficient for effective gene regulation in eukaryotes. Epigenetic factors at various levels also have an essential role: for example, DNA methylation and histone modifications form the molecular basis of gene regulation by creating chromatin microenvironments that promote or prevent transcription. Gene activation requires complete cascades of chromatin modifiers to prepare the chromatin for transcription. In addition, the topology of the chromatin and the dynamic interactions between nuclear bodies influence genome function. How the appropriate and controlled expression of genes is achieved is clearly a complicated system, both in terms of the number of interacting components and the spatial heterogeneity. In other areas of cell function that are carried out by multi‐enzyme networks, the question of how function arises from the interaction of the relevant components is being addressed by various combined theoretical and experimental approaches termed ‘systems biology’. Such an approach could determine the extent to which known interactions explain chromatin function and identify what remains to be understood. Furthermore, the combination of mathematical and computational modelling with quantitative measurements fulfils an urgent requirement, as it has the rigour to derive robust predictions that can be precisely tested against experimental observations to support or disprove hypotheses. This meeting brought together experts in chromatin function and systems biology to inform each other of the approaches and issues in their respective fields, and to explore whether they are ready to interact to develop the systems biology of chromatin function. Inevitably, few of the participants could claim to span both fields, but the two opening plenary talks by … [1]: /embed/graphic-1.gif"](?object=%22The%204th%20EMBO%20Workshop%20on%20Nuclear%20Organization%20took%20place%20between%2012%20and%2015%20October%202006%20in%20Gosau%2C%20Austria%2C%20and%20was%20organized%20by%20D.%20Jackson%2C%20R.%20van%20Driel%2C%20H.%20Lipps%20and%20H.%20Westerhoff.!%5B%5D%5B1%5D%20It%20is%20clear%20that%20DNA%20sequence%20and%20transcription%20factor%20availability%20alone%20are%20not%20sufficient%20for%20effective%20gene%20regulation%20in%20eukaryotes.%20Epigenetic%20factors%20at%20various%20levels%20also%20have%20an%20essential%20role%3A%20for%20example%2C%20DNA%20methylation%20and%20histone%20modifications%20form%20the%20molecular%20basis%20of%20gene%20regulation%20by%20creating%20chromatin%20microenvironments%20that%20promote%20or%20prevent%20transcription.%20Gene%20activation%20requires%20complete%20cascades%20of%20chromatin%20modifiers%20to%20prepare%20the%20chromatin%20for%20transcription.%20In%20addition%2C%20the%20topology%20of%20the%20chromatin%20and%20the%20dynamic%20interactions%20between%20nuclear%20bodies%20influence%20genome%20function.%20How%20the%20appropriate%20and%20controlled%20expression%20of%20genes%20is%20achieved%20is%20clearly%20a%20complicated%20system%2C%20both%20in%20terms%20of%20the%20number%20of%20interacting%20components%20and%20the%20spatial%20heterogeneity.%20In%20other%20areas%20of%20cell%20function%20that%20are%20carried%20out%20by%20multi%E2%80%90enzyme%20networks%2C%20the%20question%20of%20how%20function%20arises%20from%20the%20interaction%20of%20the%20relevant%20components%20is%20being%20addressed%20by%20various%20combined%20theoretical%20and%20experimental%20approaches%20termed%20%E2%80%98systems%20biology%E2%80%99.%20Such%20an%20approach%20could%20determine%20the%20extent%20to%20which%20known%20interactions%20explain%20chromatin%20function%20and%20identify%20what%20remains%20to%20be%20understood.%20Furthermore%2C%20the%20combination%20of%20mathematical%20and%20computational%20modelling%20with%20quantitative%20measurements%20fulfils%20an%20urgent%20requirement%2C%20as%20it%20has%20the%20rigour%20to%20derive%20robust%20predictions%20that%20can%20be%20precisely%20tested%20against%20experimental%20observations%20to%20support%20or%20disprove%20hypotheses.%20This%20meeting%20brought%20together%20experts%20in%20chromatin%20function%20and%20systems%20biology%20to%20inform%20each%20other%20of%20the%20approaches%20and%20issues%20in%20their%20respective%20fields%2C%20and%20to%20explore%20whether%20they%20are%20ready%20to%20interact%20to%20develop%20the%20systems%20biology%20of%20chromatin%20function.%20Inevitably%2C%20few%20of%20the%20participants%20could%20claim%20to%20span%20both%20fields%2C%20but%20the%20two%20opening%20plenary%20talks%20by%20%E2%80%A6%20%5B1%5D%3A%20%2Fembed%2Fgraphic-1.gif%22){kind=link}