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- W2115096720 abstract "The growth and maintenance of the mammary gland requires both steroid and polypeptide hormones. Malignant growth in this tissue may also be hormonally dependent. As a consequence, the ablation of hormoneproducing organs, such as the pituitary and adrenal glands, may benefit about half the patients with advanced breast cancer after mastectomy. Not all patients respond to endocrine ablation, however, and methods are required for selecting the patients who are most likely to benefit. Since hormonal imbalance is an etiological feature of breast cancer, the selection of patients for adrenalectomy could be based on either measurement of hormone levels themselves or other biochemical parameters that reflect this change in hormonal status. Of the methods based on levels of endogenous hormones, the discriminant method (1) is the most widely used. The results obtained in a large prospective trial in Guernsey (Channel Islands) (2) indicate the discriminant is of prognostic value even before the disease is manifest. In the discriminant method, the hormonal imbalance is reflected in changes in urinary levels of 1 7-hydroxycorticosteroids and etiocholanolone. An alternate method uses the ratio of urinary 1 1-deoxy-1 7-oxosteroids (3). As sensitive metabolic changes may be apparent before significant alterations in hormonal levels can be measured, an attempt has been made to correlate the discriminant with possible biochemical indicators of hormonal imbalance. The choice of tryptophan metabolites for this purpose was prompted by the work of Rose (4, 5), who attributed the elevation of the excretion of tryptophan metabolites in breast cancer patients to a stimulation of hepatic catabolism by estrogens. In the work to be described, the discriminant, urinary steroid ratio, and the excretory pattern of tryptophan metabolites were measured concurrently in a large group of breast cancer patients and in normal women." @default.
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- W2115096720 date "1971-06-01" @default.
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- W2115096720 title "Relationships between excretion of steroid hormones and tryptophan metabolites in patients with breast cancer" @default.
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- W2115096720 doi "https://doi.org/10.1093/ajcn/24.6.694" @default.
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