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• W2115135095 abstract "AbstractObjectives: To study blood flow characteristics through the internal jugular veins (IJVs) at the cervical levels C2/C3 and C5/C6 in the neck of multiple sclerosis (MS) patients.Methods: Magnetic resonance imaging at 3T was performed on 323 MS patients. Phase contrast imaging was used to quantify blood flow at both the C2/C3 and C5/C6 levels. Total IJV flow (tIJF) was normalized by total arterial flow (tAF). Contrast-enhanced time-resolved 3D MR arteriovenography and 2D time-of-flight MR venography were performed to assess IJV anatomy. Based on this assessment, the MS population was divided into non-stenotic (NST) and stenotic (ST) subjects.Results: Of all the patients, 100 (31%) belonged to the NST group and 223 (69%) belonged to the ST group. At the C2/C3 and C5/C6 levels, the normalized tIJF of the ST group was 56±26% and 51±23%, respectively. This was significantly lower than that of the NST group, 85±13% and 73±12% (P<0·001). Zero percent and 5% of the NST group had a normalized tIJF of less than 50% at the C2/C3 and C5/C6 levels, compared to 37% and 47% for the ST group. The tAF was smaller for the secondary and primary progressive MS patients than the relapsing remitting MS patients (P = 0·02 and 0·01, respectively), while the tIJF was similar among all MS types.Conclusion: Total blood flow through the IJVs at both the C2/C3 and C5/C6 levels was reduced in the ST group compared to the NST group.Keywords: Internal jugular veinsFlow abnormalitiesMultiple sclerosisChronic cerebrospinal venous insufficiencyMagnetic resonance angiographyPhase contrast imaging" @default.
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• W2115135095 date "2012-10-01" @default.
• W2115135095 modified "2023-10-18" @default.
• W2115135095 title "Characteristics of flow through the internal jugular veins at cervical C2/C3 and C5/C6 levels for multiple sclerosis patients using MR phase contrast imaging" @default.
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• W2115135095 doi "https://doi.org/10.1179/1743132812y.0000000079" @default.
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