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• W2115136789 abstract "In their recent paper, Richardson et al1Richardson D Bartlett C Will EJ Optimizing erythropoietin therapy in hemodialysis patients.Am J Kidney Dis. 2001; 38: 109-117Abstract Full Text Full Text PDF PubMed Scopus (50) Google Scholar describe a computer-aided decision system for erythropoietin and intravenous iron therapy for optimal management of anemia in a cohort of patients on hemodialysis. A major aim of their intravenous iron replacement protocol is to reduce percentage of hypochromic red cells (HRC) to <2% and thus avoid functional iron deficiency and a suboptimal response to erythropoietin therapy. It is well known that storage of full blood count (FBC) samples at room temperature leads to a factitious elevation of mean cell volume (MCV) due to swelling of red blood cells.2Bain BJ Blood Cells. A Practical Guide.in: ed 2. Blackwell Science, London, UK1995: 136-137Google Scholar However, we wish to report that storage of FBC samples at room temperature also leads to erroneous increases in HRC. After informed consent was obtained, blood was taken from 10 healthy volunteers and FBC and HRC were measured in a Bayer ADVIA 120 automated blood count analyzer (Bayer PLC, Diagnostics Division, Newbury, UK) at time of blood collection and after 8 hours and 24 hours of blood specimen storage at room temperature (25°C). Although hemoglobin concentrations remained unchanged on storage, mean MCV (±SD) increased from 90.49 fL (±2.7) at the time of collection to 94.23 fL (±2.89) at 8 hours and to 96.58 fL (±3.39) at 24 hours of storage. The mean HRC increased from 0.1% (±0.16%; range, 0% to 0.5%) to 2.12% (±1.84; range, 0.3% to 6.7%) at 8 hours and to 5.46% (±4.48%; range, 0.9% to 12.8%) at 24 hours of storage. We conclude that, after 8 hours of storage, there is already a marked increase in HRC due to red blood cell swelling compared with HRC measured at time of blood sampling. Given that small changes in HRC appear to be important in guiding the amount of intravenous iron transfused to hemodialysed patients, we believe that renal physicians should be aware of the possibility of erroneous increases in HRC on storage of FBC samples and ensure that delays between collection of patient FBC samples and their processing through automated blood count analyzers are kept to a minimum." @default.
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• W2115136789 date "2002-05-01" @default.
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• W2115136789 title "Storage of full blood count samples causes a factitious increase in percentage of hypochromic cells" @default.
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• W2115136789 doi "https://doi.org/10.1053/ajkd.2002.33449" @default.
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