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• W2115174652 abstract "Several studies suggest links between cancer and tricyclic antidepressant use.A case-control study using the General Practice Research Database examined whether previous tricyclic usage was associated with reduced incidence of brain (with glioma as a sub-category), breast, colorectal, lung and prostate cancers. Conditional logistic regression adjusted for age, gender, general practice, depression, smoking, body mass index, alcohol use and non-steroidal anti-inflammatory drug use.A total of 31 953 cancers were identified, each matched with up to two controls. We found a statistically significant reduction in tricyclic prescriptions compared with controls in glioma (odds ratio (OR) =0.59, 95% confidence interval (CI)=0.42-0.81) and colorectal cancer patients (OR=0.84, CI=0.75-0.94). These effects were dose-dependent (P-values for trend, glioma=0.0005, colorectal=0.001) and time-dependant (P-values for trend glioma=0.0005, colorectal=0.0086). The effects were cancer-type specific, with lung, breast and prostate cancers largely unaffected by antidepressant use.The biologically plausible, specific and dose- and time-dependant inverse association that we have found suggests that tricyclics may have potential for prevention of both colorectal cancer and glioma." @default.
• W2115174652 created "2016-06-24" @default.
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• W2115174652 date "2010-11-16" @default.
• W2115174652 modified "2023-10-16" @default.
• W2115174652 title "Tricyclic antidepressants and the incidence of certain cancers: a study using the GPRD" @default.
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• W2115174652 doi "https://doi.org/10.1038/sj.bjc.6605996" @default.
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