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- W2115177875 endingPage "438" @default.
- W2115177875 startingPage "424" @default.
- W2115177875 abstract "One of the obstacles to a better understanding of the pathogenesis of human cardiomyopathies has been poor availability of heart-tissue samples at early stages of disease development. This has possibly changed by the advent of patient-derived induced pluripotent stem cell (hiPSC) from which cardiomyocytes can be derived in vitro. The main promise of hiPSC technology is that by capturing the effects of thousands of individual gene variants, the phenotype of differentiated derivatives of these cells will provide more information on a particular disease than simple genotyping. This article summarizes what is known about the ‘human cardiomyopathy or heart failure phenotype in vitro’, which constitutes the reference for modelling sarcomeric cardiomyopathies in hiPSC-derived cardiomyocytes. The current techniques for hiPSC generation and cardiac myocyte differentiation are briefly reviewed and the few published reports of hiPSC models of sarcomeric cardiomyopathies described. A discussion of promises and challenges of hiPSC-modelling of sarcomeric cardiomyopathies and individualized approaches is followed by a number of questions that, in the view of the authors, need to be answered before the true potential of this technology can be evaluated." @default.
- W2115177875 created "2016-06-24" @default.
- W2115177875 creator A5011450375 @default.
- W2115177875 creator A5064477997 @default.
- W2115177875 creator A5085628953 @default.
- W2115177875 date "2015-01-24" @default.
- W2115177875 modified "2023-10-02" @default.
- W2115177875 title "Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes" @default.
- W2115177875 cites W1600467604 @default.
- W2115177875 cites W1963623014 @default.
- W2115177875 cites W1964747697 @default.
- W2115177875 cites W1967428301 @default.
- W2115177875 cites W1967753406 @default.
- W2115177875 cites W1969832018 @default.
- W2115177875 cites W1970727687 @default.
- W2115177875 cites W1971590660 @default.
- W2115177875 cites W1972370207 @default.
- W2115177875 cites W1972660539 @default.
- W2115177875 cites W1977025496 @default.
- W2115177875 cites W1978578637 @default.
- W2115177875 cites W1979659033 @default.
- W2115177875 cites W1982580210 @default.
- W2115177875 cites W1982580326 @default.
- W2115177875 cites W1986595047 @default.
- W2115177875 cites W1988290340 @default.
- W2115177875 cites W1988456417 @default.
- W2115177875 cites W1988675802 @default.
- W2115177875 cites W1989282030 @default.
- W2115177875 cites W1989456266 @default.
- W2115177875 cites W1990810165 @default.
- W2115177875 cites W1991234590 @default.
- W2115177875 cites W1992011889 @default.
- W2115177875 cites W1997304392 @default.
- W2115177875 cites W1997609921 @default.
- W2115177875 cites W1997842787 @default.
- W2115177875 cites W1999148174 @default.
- W2115177875 cites W1999251970 @default.
- W2115177875 cites W2000967710 @default.
- W2115177875 cites W2005522698 @default.
- W2115177875 cites W2007533297 @default.
- W2115177875 cites W2010007998 @default.
- W2115177875 cites W2010020475 @default.
- W2115177875 cites W2013318331 @default.
- W2115177875 cites W2017495453 @default.
- W2115177875 cites W2018463503 @default.
- W2115177875 cites W2018474760 @default.
- W2115177875 cites W2019668085 @default.
- W2115177875 cites W2022229270 @default.
- W2115177875 cites W2023315677 @default.
- W2115177875 cites W2024763420 @default.
- W2115177875 cites W2025666521 @default.
- W2115177875 cites W2026404421 @default.
- W2115177875 cites W2026902924 @default.
- W2115177875 cites W2029050944 @default.
- W2115177875 cites W2029904491 @default.
- W2115177875 cites W2030290211 @default.
- W2115177875 cites W2030297656 @default.
- W2115177875 cites W2030526351 @default.
- W2115177875 cites W2031383358 @default.
- W2115177875 cites W2033765226 @default.
- W2115177875 cites W2033877733 @default.
- W2115177875 cites W2034862301 @default.
- W2115177875 cites W2035312069 @default.
- W2115177875 cites W2036663915 @default.
- W2115177875 cites W2037083085 @default.
- W2115177875 cites W2038117952 @default.
- W2115177875 cites W2042091538 @default.
- W2115177875 cites W2045202330 @default.
- W2115177875 cites W2046110995 @default.
- W2115177875 cites W2046848012 @default.
- W2115177875 cites W2047998219 @default.
- W2115177875 cites W2054739801 @default.
- W2115177875 cites W2056956652 @default.
- W2115177875 cites W2057459836 @default.
- W2115177875 cites W2059060273 @default.
- W2115177875 cites W2065740657 @default.
- W2115177875 cites W2066390373 @default.
- W2115177875 cites W2066767635 @default.
- W2115177875 cites W2067121447 @default.
- W2115177875 cites W2068204822 @default.
- W2115177875 cites W2070536183 @default.
- W2115177875 cites W2071053944 @default.
- W2115177875 cites W2073377349 @default.
- W2115177875 cites W2074070702 @default.
- W2115177875 cites W2074688769 @default.
- W2115177875 cites W2079592630 @default.
- W2115177875 cites W2082823804 @default.
- W2115177875 cites W2085050235 @default.
- W2115177875 cites W2087773341 @default.
- W2115177875 cites W2088236700 @default.
- W2115177875 cites W2088470456 @default.
- W2115177875 cites W2088483457 @default.
- W2115177875 cites W2091445641 @default.
- W2115177875 cites W2094057283 @default.
- W2115177875 cites W2096151652 @default.
- W2115177875 cites W2096579994 @default.
- W2115177875 cites W2098466621 @default.
- W2115177875 cites W2102389881 @default.