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• W2115183629 endingPage "1305" @default.
• W2115183629 startingPage "1283" @default.
• W2115183629 abstract "This review examines the dynamics of parathyroid hormone secretion in health and in various causes of secondary hyperparathyroidism. Although most studies of parathyroid hormone and calcium have focused on the modification of parathyroid hormone secretion by serum calcium, the relationship between parathyroid hormone and serum calcium is bifunctional because parathyroid hormone also modifies serum calcium. In normal animals and humans, factors such as phosphorus and vitamin D modify the basal parathyroid hormone level and the maximal parathyroid hormone response to hypocalcemia. Certain medications, such as lithium and estrogen, in normal individuals and sustained changes in the serum calcium concentration in hemodialysis patients change the set point of calcium, which reflects the serum calcium concentration at which parathyroid hormone secretion responds. Hypocalcemia increases the basal/maximal parathyroid hormone ratio, a measure of the relative degree of parathyroid hormone stimulation. The phenomenon of hysteresis, defined as a different parathyroid hormone value for the same serum calcium concentration during the induction of and recovery from hypo- and hypercalcemia, is discussed because it provides important insights into factors that affect parathyroid hormone secretion. In three causes of secondary hyperparathyroidism—chronic kidney disease, vitamin D deficiency, and aging—factors that affect the dynamics of parathyroid hormone secretion are evaluated in detail. During recovery from vitamin D deficiency, the maximal parathyroid hormone remains elevated while the basal parathyroid hormone value rapidly becomes normal because of a shift in the set point of calcium. Much remains to be learned about the dynamics of parathyroid hormone secretion in health and secondary hyperparathyroidism." @default.
• W2115183629 created "2016-06-24" @default.
• W2115183629 creator A5013963480 @default.
• W2115183629 creator A5058079189 @default.
• W2115183629 creator A5090524109 @default.
• W2115183629 date "2007-11-01" @default.
• W2115183629 modified "2023-10-18" @default.
• W2115183629 title "Dynamics of Parathyroid Hormone Secretion in Health and Secondary Hyperparathyroidism" @default.
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