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- W2115203110 abstract "Abstract Cyclooxygenase-2 (COX-2) is being intensively evaluated as a pharmacologic target for both the prevention and treatment of cancer. Aberrant COX-2 expression was initially described in colorectal cancers and has now been detected in many human tumors, including breast cancers. Strikingly, forced expression of COX-2 in murine mammary gland drives tumor formation. Moreover, knocking out COX-2 protects against the formation of intestinal and skin tumors in animal cancer models. Consistent with these findings, selective COX-2 inhibitors possess anticancer properties. For example, selective COX-2 inhibitors reduce the formation and growth of experimental breast and colon cancers. Importantly, selective COX-2 inhibitors do not inhibit platelet function and cause fewer gastrointestinal side effects (peptic ulcer disease) than traditional nonsteroidal anti-inflammatory drugs. Clinical trials are warranted to define the role of selective COX-2 inhibitors in the prevention and treatment of cancer. Semin Oncol 29 (suppl 11):111-119. Copyright 2002, Elsevier Science (USA). All rights reserved." @default.
- W2115203110 created "2016-06-24" @default.
- W2115203110 creator A5002205579 @default.
- W2115203110 creator A5013077524 @default.
- W2115203110 date "2002-01-01" @default.
- W2115203110 modified "2023-10-16" @default.
- W2115203110 title "A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer" @default.
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- W2115203110 doi "https://doi.org/10.1016/s0093-7754(02)70134-6" @default.