Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115210006> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2115210006 abstract "Isocitrate dehydrogenase 1 (IDH1) and Succinate dehydrogenase (SDH) mutant tumors may have increased levels of hypoxia inducible factor (HIF), which leads to a tumoral pseudohypoxic profile. Increased HIF levels may promote tumor progression by the activation of numerous cellular processes including resistance to apoptosis, vascular remodeling and angiogenesis. A high frequency of IDH1 mutations has been detected in adult but not in pediatric gliomas. However, loss of SDH expression has not been investigated in gliomas. To further explore the profile and possible contribution of IDH1 and SDHB to glioma tumorigenesis, we investigated the expression of IDH1-R132 mutant and SDHB in a series of 94 histologically confirmed pediatric and adult gliomas. There were 13 diffuse intrinsic pontine gliomas and 81 adult gliomas: 10 lowgrade astrocytomas 8 oligodendrogliomas, 4 ependymomas and 59 glioblastomas (GBMs). Pediatric brain stem gliomas were negative for mutant IDH1 (0/13) and showed preserved SDHB expression (13/13). IDH1 mutant tumors included 6/10 astrocytomas, 5/8 oligodendrogliomas, 0/4 ependymomas and 13/59 GBMs. No adult or pediatric glioma exhibited loss of SDHB expression. IDH1 mutations are frequently present in low- and high-grade gliomas, but not in pediatric brain stem gliomas. It appears that IDH1, but not SDHB, contributes to HIF stabilization in adult gliomas. However, IDH1 or SDHB alterations do not appear to play a role in pediatric gliomagenesis." @default.
- W2115210006 created "2016-06-24" @default.
- W2115210006 creator A5002738255 @default.
- W2115210006 creator A5016039890 @default.
- W2115210006 creator A5022375331 @default.
- W2115210006 creator A5023641339 @default.
- W2115210006 creator A5024934444 @default.
- W2115210006 creator A5027825081 @default.
- W2115210006 creator A5071583950 @default.
- W2115210006 creator A5076923637 @default.
- W2115210006 creator A5085503475 @default.
- W2115210006 date "2014-01-01" @default.
- W2115210006 modified "2023-09-25" @default.
- W2115210006 title "Expression of IDH1 Mutant Protein R132H and SDHB in Adult and Pediatric Gliomas" @default.
- W2115210006 cites W1964150693 @default.
- W2115210006 cites W1966741747 @default.
- W2115210006 cites W1981005501 @default.
- W2115210006 cites W1988756388 @default.
- W2115210006 cites W2025719835 @default.
- W2115210006 cites W2057199368 @default.
- W2115210006 cites W2080452140 @default.
- W2115210006 cites W2083954708 @default.
- W2115210006 cites W2086945799 @default.
- W2115210006 cites W2116562310 @default.
- W2115210006 cites W2126817554 @default.
- W2115210006 cites W2139631829 @default.
- W2115210006 cites W2148977460 @default.
- W2115210006 cites W2313691801 @default.
- W2115210006 doi "https://doi.org/10.7726/ijn.2014.1003" @default.
- W2115210006 hasPublicationYear "2014" @default.
- W2115210006 type Work @default.
- W2115210006 sameAs 2115210006 @default.
- W2115210006 citedByCount "0" @default.
- W2115210006 crossrefType "journal-article" @default.
- W2115210006 hasAuthorship W2115210006A5002738255 @default.
- W2115210006 hasAuthorship W2115210006A5016039890 @default.
- W2115210006 hasAuthorship W2115210006A5022375331 @default.
- W2115210006 hasAuthorship W2115210006A5023641339 @default.
- W2115210006 hasAuthorship W2115210006A5024934444 @default.
- W2115210006 hasAuthorship W2115210006A5027825081 @default.
- W2115210006 hasAuthorship W2115210006A5071583950 @default.
- W2115210006 hasAuthorship W2115210006A5076923637 @default.
- W2115210006 hasAuthorship W2115210006A5085503475 @default.
- W2115210006 hasConcept C104317684 @default.
- W2115210006 hasConcept C127848430 @default.
- W2115210006 hasConcept C13514818 @default.
- W2115210006 hasConcept C143065580 @default.
- W2115210006 hasConcept C185592680 @default.
- W2115210006 hasConcept C2780744430 @default.
- W2115210006 hasConcept C501734568 @default.
- W2115210006 hasConcept C502942594 @default.
- W2115210006 hasConcept C54355233 @default.
- W2115210006 hasConcept C6856738 @default.
- W2115210006 hasConcept C71924100 @default.
- W2115210006 hasConcept C86803240 @default.
- W2115210006 hasConceptScore W2115210006C104317684 @default.
- W2115210006 hasConceptScore W2115210006C127848430 @default.
- W2115210006 hasConceptScore W2115210006C13514818 @default.
- W2115210006 hasConceptScore W2115210006C143065580 @default.
- W2115210006 hasConceptScore W2115210006C185592680 @default.
- W2115210006 hasConceptScore W2115210006C2780744430 @default.
- W2115210006 hasConceptScore W2115210006C501734568 @default.
- W2115210006 hasConceptScore W2115210006C502942594 @default.
- W2115210006 hasConceptScore W2115210006C54355233 @default.
- W2115210006 hasConceptScore W2115210006C6856738 @default.
- W2115210006 hasConceptScore W2115210006C71924100 @default.
- W2115210006 hasConceptScore W2115210006C86803240 @default.
- W2115210006 hasLocation W21152100061 @default.
- W2115210006 hasOpenAccess W2115210006 @default.
- W2115210006 hasPrimaryLocation W21152100061 @default.
- W2115210006 hasRelatedWork W2047867594 @default.
- W2115210006 hasRelatedWork W2094851085 @default.
- W2115210006 hasRelatedWork W2115210006 @default.
- W2115210006 hasRelatedWork W2740327985 @default.
- W2115210006 hasRelatedWork W2748952813 @default.
- W2115210006 hasRelatedWork W2767753965 @default.
- W2115210006 hasRelatedWork W2767996840 @default.
- W2115210006 hasRelatedWork W2899084033 @default.
- W2115210006 hasRelatedWork W4255489562 @default.
- W2115210006 hasRelatedWork W4362623847 @default.
- W2115210006 isParatext "false" @default.
- W2115210006 isRetracted "false" @default.
- W2115210006 magId "2115210006" @default.
- W2115210006 workType "article" @default.