FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115220489> ?p ?o ?g. }

• W2115220489 endingPage "3424" @default.
• W2115220489 startingPage "3417" @default.
• W2115220489 abstract "Sphingosine kinase-1 (SphK1) was shown in preclinical models and non-genitourinary cancers to be instrumental in cancer progression, adaptation to hypoxia and in tumour angiogenesis. No data were available in human prostate cancer. The present study was designed to assess SphK1 expression and activity in radical prostatectomy specimens and to research correlations with clinical features.Transverse section of fresh tissue was obtained from 30 consecutive patients undergoing laparoscopic prostatectomy. SphK1 enzymatic activities of tumour and normal counterpart were determined. Relationships with PSA, Gleason sum, pathological stage, resection margin status and treatment failure were researched. SphK1 pattern of expression was then assessed on tissue microarray.A significant 2-fold increase in SphK1 enzymatic activity(11.1 ± 8.4 versus 5.9 ± 3.2 (P<0.04)) was observed in cancer. The upper quartile of SphK1 activity was associated with higher PSA (16.7 versus 6.4 ng/ml, P = 0.04), higher tumor volumes (20.7 versus 9.8, P = 0.002), higher rates of positive margins (85.7% versus 28.6%, P = 0.01) and surgical failure (71.4% versus 9.5%, P = 0.003) than the lower three quartiles. Odds ratios (OR) for treatment failure showed a strong relationship with SphK1 activity (OR: 23.7, P = 0.001), positive resection margins (OR: 15.0, P = 0.007) and Gleason sum (≥4+3, OR: 8.0, P = 0.003). Tissue microarrays showed discrete epithelial expression that varied with Gleason sum with significant relationship between SphK1 expression and higher Gleason sum.In complement to preclinical literature, the demonstrated relationships between SphK1-increased activity in cancer and relevant clinical features confirm a central role for SphK1 in prostate cancer that herald promising avenues in risk-assessment and treatment." @default.
• W2115220489 created "2016-06-24" @default.
• W2115220489 creator A5005618200 @default.
• W2115220489 creator A5009584708 @default.
• W2115220489 creator A5010275444 @default.
• W2115220489 creator A5013710422 @default.
• W2115220489 creator A5024804600 @default.
• W2115220489 creator A5025314043 @default.
• W2115220489 creator A5032213369 @default.
• W2115220489 creator A5055237349 @default.
• W2115220489 creator A5058869400 @default.
• W2115220489 date "2010-12-01" @default.
• W2115220489 modified "2023-10-17" @default.
• W2115220489 title "Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens" @default.
• W2115220489 cites W1966452335 @default.
• W2115220489 cites W1969996654 @default.
• W2115220489 cites W1977368133 @default.
• W2115220489 cites W1977644244 @default.
• W2115220489 cites W1978465583 @default.
• W2115220489 cites W2015354948 @default.
• W2115220489 cites W2018146992 @default.
• W2115220489 cites W2022589671 @default.
• W2115220489 cites W2022770236 @default.
• W2115220489 cites W2023922025 @default.
• W2115220489 cites W2030377279 @default.
• W2115220489 cites W2035936829 @default.
• W2115220489 cites W205075771 @default.
• W2115220489 cites W2052788204 @default.
• W2115220489 cites W2053310582 @default.
• W2115220489 cites W2057163959 @default.
• W2115220489 cites W2079770872 @default.
• W2115220489 cites W2083419605 @default.
• W2115220489 cites W2087792530 @default.
• W2115220489 cites W2096273281 @default.
• W2115220489 cites W2101672301 @default.
• W2115220489 cites W2101995865 @default.
• W2115220489 cites W2108091182 @default.
• W2115220489 cites W2110388058 @default.
• W2115220489 cites W2114927528 @default.
• W2115220489 cites W2117773251 @default.
• W2115220489 cites W2118095617 @default.
• W2115220489 cites W2121559592 @default.
• W2115220489 cites W2123230901 @default.
• W2115220489 cites W2124496728 @default.
• W2115220489 cites W2125144175 @default.
• W2115220489 cites W2132805096 @default.
• W2115220489 cites W2137227557 @default.
• W2115220489 cites W2140636998 @default.
• W2115220489 cites W2144464933 @default.
• W2115220489 cites W2145432699 @default.
• W2115220489 cites W2154770245 @default.
• W2115220489 cites W2166720487 @default.
• W2115220489 cites W2171242956 @default.
• W2115220489 cites W2240279274 @default.
• W2115220489 cites W2283847485 @default.
• W2115220489 cites W2323868208 @default.
• W2115220489 doi "https://doi.org/10.1016/j.ejca.2010.07.053" @default.
• W2115220489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20970322" @default.
• W2115220489 hasPublicationYear "2010" @default.
• W2115220489 type Work @default.
• W2115220489 sameAs 2115220489 @default.
• W2115220489 citedByCount "77" @default.
• W2115220489 countsByYear W21152204892012 @default.
• W2115220489 countsByYear W21152204892013 @default.
• W2115220489 countsByYear W21152204892014 @default.
• W2115220489 countsByYear W21152204892015 @default.
• W2115220489 countsByYear W21152204892016 @default.
• W2115220489 countsByYear W21152204892017 @default.
• W2115220489 countsByYear W21152204892018 @default.
• W2115220489 countsByYear W21152204892019 @default.
• W2115220489 countsByYear W21152204892020 @default.
• W2115220489 countsByYear W21152204892021 @default.
• W2115220489 countsByYear W21152204892022 @default.
• W2115220489 countsByYear W21152204892023 @default.
• W2115220489 crossrefType "journal-article" @default.
• W2115220489 hasAuthorship W2115220489A5005618200 @default.
• W2115220489 hasAuthorship W2115220489A5009584708 @default.
• W2115220489 hasAuthorship W2115220489A5010275444 @default.
• W2115220489 hasAuthorship W2115220489A5013710422 @default.
• W2115220489 hasAuthorship W2115220489A5024804600 @default.
• W2115220489 hasAuthorship W2115220489A5025314043 @default.
• W2115220489 hasAuthorship W2115220489A5032213369 @default.
• W2115220489 hasAuthorship W2115220489A5055237349 @default.
• W2115220489 hasAuthorship W2115220489A5058869400 @default.
• W2115220489 hasConcept C121608353 @default.
• W2115220489 hasConcept C126322002 @default.
• W2115220489 hasConcept C126894567 @default.
• W2115220489 hasConcept C133507102 @default.
• W2115220489 hasConcept C142724271 @default.
• W2115220489 hasConcept C143998085 @default.
• W2115220489 hasConcept C170493617 @default.
• W2115220489 hasConcept C193270364 @default.
• W2115220489 hasConcept C2776235491 @default.
• W2115220489 hasConcept C2776596873 @default.
• W2115220489 hasConcept C2777550365 @default.
• W2115220489 hasConcept C2778703144 @default.
• W2115220489 hasConcept C2779466945 @default.
• W2115220489 hasConcept C2780192828 @default.

• next