FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115280360> ?p ?o ?g. }

• W2115280360 endingPage "10240" @default.
• W2115280360 startingPage "10230" @default.
• W2115280360 abstract "ABSTRACT Nevirapine forms the mainstay of our efforts to curtail the pediatric AIDS epidemic through prevention of mother-to-child transmission of HIV-1. A key limitation, however, is the rapid selection of HIV-1 strains resistant to nevirapine following the administration of a single dose. This rapid selection of resistance suggests that nevirapine-resistant strains preexist in HIV-1 patients and may adversely affect outcomes of treatment. The frequencies of nevirapine-resistant strains in vivo , however, remain poorly estimated, possibly because they exist as a minority below current assay detection limits. Here, we employ stochastic simulations and a mathematical model to estimate the frequencies of strains carrying different combinations of the common nevirapine resistance mutations K103N, V106A, Y181C, Y188C, and G190A in chronically infected HIV-1 patients naïve to nevirapine. We estimate the relative fitness of mutant strains from an independent analysis of previous competitive growth assays. We predict that single mutants are likely to preexist in patients at frequencies (∼0.01% to 0.001%) near or below current assay detection limits (>0.01%), emphasizing the need for more-sensitive assays. The existence of double mutants is subject to large stochastic variations. Triple and higher mutants are predicted not to exist. Our estimates are robust to variations in the recombination rate, cellular superinfection frequency, and the effective population size. Thus, with 10 7 to 10 8 infected cells in HIV-1 patients, even when undetected, nevirapine-resistant genomes may exist in substantial numbers and compromise efforts to prevent mother-to-child transmission of HIV-1, accelerate the failure of subsequent antiretroviral treatments, and facilitate the transmission of drug resistance." @default.
• W2115280360 created "2016-06-24" @default.
• W2115280360 creator A5009087944 @default.
• W2115280360 creator A5034345828 @default.
• W2115280360 date "2010-10-01" @default.
• W2115280360 modified "2023-09-26" @default.
• W2115280360 title "Estimating Frequencies of Minority Nevirapine-Resistant Strains in Chronically HIV-1-Infected Individuals Naïve to Nevirapine by Using Stochastic Simulations and a Mathematical Model" @default.
• W2115280360 cites W1557952727 @default.
• W2115280360 cites W1564649778 @default.
• W2115280360 cites W1955688637 @default.
• W2115280360 cites W1963618985 @default.
• W2115280360 cites W1966063036 @default.
• W2115280360 cites W1966771136 @default.
• W2115280360 cites W1982200480 @default.
• W2115280360 cites W1983297428 @default.
• W2115280360 cites W1987858510 @default.
• W2115280360 cites W1990105675 @default.
• W2115280360 cites W1995278079 @default.
• W2115280360 cites W2002574877 @default.
• W2115280360 cites W2014366116 @default.
• W2115280360 cites W2019286230 @default.
• W2115280360 cites W2038602178 @default.
• W2115280360 cites W2044373215 @default.
• W2115280360 cites W2052381091 @default.
• W2115280360 cites W2060534902 @default.
• W2115280360 cites W2061536824 @default.
• W2115280360 cites W2061657962 @default.
• W2115280360 cites W2063950143 @default.
• W2115280360 cites W2065608903 @default.
• W2115280360 cites W2067880257 @default.
• W2115280360 cites W2074863393 @default.
• W2115280360 cites W2074918485 @default.
• W2115280360 cites W2075130810 @default.
• W2115280360 cites W2080237955 @default.
• W2115280360 cites W2081745197 @default.
• W2115280360 cites W2083071974 @default.
• W2115280360 cites W2087734376 @default.
• W2115280360 cites W2088567145 @default.
• W2115280360 cites W2096310657 @default.
• W2115280360 cites W2101516953 @default.
• W2115280360 cites W2103731776 @default.
• W2115280360 cites W2104759966 @default.
• W2115280360 cites W2104966707 @default.
• W2115280360 cites W2106197195 @default.
• W2115280360 cites W2107033172 @default.
• W2115280360 cites W2114705914 @default.
• W2115280360 cites W2118299879 @default.
• W2115280360 cites W2118435139 @default.
• W2115280360 cites W2130852416 @default.
• W2115280360 cites W2132996732 @default.
• W2115280360 cites W2138106725 @default.
• W2115280360 cites W2139185068 @default.
• W2115280360 cites W2146906064 @default.
• W2115280360 cites W2147413871 @default.
• W2115280360 cites W2148684707 @default.
• W2115280360 cites W2151856127 @default.
• W2115280360 cites W2153977602 @default.
• W2115280360 cites W2154283429 @default.
• W2115280360 cites W2157380363 @default.
• W2115280360 cites W2157722508 @default.
• W2115280360 cites W2165657851 @default.
• W2115280360 cites W2166147286 @default.
• W2115280360 cites W2166434950 @default.
• W2115280360 cites W2170219825 @default.
• W2115280360 cites W2314791685 @default.
• W2115280360 doi "https://doi.org/10.1128/jvi.01010-10" @default.
• W2115280360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2937761" @default.
• W2115280360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20668070" @default.
• W2115280360 hasPublicationYear "2010" @default.
• W2115280360 type Work @default.
• W2115280360 sameAs 2115280360 @default.
• W2115280360 citedByCount "25" @default.
• W2115280360 countsByYear W21152803602012 @default.
• W2115280360 countsByYear W21152803602013 @default.
• W2115280360 countsByYear W21152803602014 @default.
• W2115280360 countsByYear W21152803602015 @default.
• W2115280360 countsByYear W21152803602016 @default.
• W2115280360 countsByYear W21152803602018 @default.
• W2115280360 countsByYear W21152803602019 @default.
• W2115280360 countsByYear W21152803602020 @default.
• W2115280360 countsByYear W21152803602021 @default.
• W2115280360 countsByYear W21152803602022 @default.
• W2115280360 crossrefType "journal-article" @default.
• W2115280360 hasAuthorship W2115280360A5009087944 @default.
• W2115280360 hasAuthorship W2115280360A5034345828 @default.
• W2115280360 hasBestOaLocation W21152803602 @default.
• W2115280360 hasConcept C114851261 @default.
• W2115280360 hasConcept C142462285 @default.
• W2115280360 hasConcept C159047783 @default.
• W2115280360 hasConcept C2779130552 @default.
• W2115280360 hasConcept C2908647359 @default.
• W2115280360 hasConcept C2993143319 @default.
• W2115280360 hasConcept C3013748606 @default.
• W2115280360 hasConcept C41008148 @default.
• W2115280360 hasConcept C54355233 @default.
• W2115280360 hasConcept C71924100 @default.
• W2115280360 hasConcept C761482 @default.
• W2115280360 hasConcept C76155785 @default.

• next