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• W2115280863 abstract "Sphingosine-1-phosphate (S1P) binds to and signals through several members of a group of G protein-coupled receptors (GPCRs) known as the S1P/EDG family. Several of these receptors are coexpressed in various cell types and recent reports have shown that biological effects of S1P often require more than one S1P receptor subtype. Recent evidence indicates that many GPCRs exist as dimers. We show that S1P receptors form both homodimers as well as heterodimers with other members of the S1P subfamily of receptors. We also discuss the role that GPCR dimers play in receptor function and what this may mean for S1P signaling." @default.
• W2115280863 created "2016-06-24" @default.
• W2115280863 creator A5001837381 @default.
• W2115280863 creator A5044325152 @default.
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• W2115280863 date "2002-05-23" @default.
• W2115280863 modified "2023-09-26" @default.
• W2115280863 title "Homodimerization and heterodimerization of S1P/EDG sphingosine-1-phosphate receptors" @default.
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• W2115280863 doi "https://doi.org/10.1016/s1388-1981(02)00141-5" @default.
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