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- W2115285855 abstract "Bacteria are continually bombarded by a multitude of chemicals from their environment, some of which may serve as potential sources of carbon, nitrogen, and energy, while others may act as poisons of their metabolic and regulatory processes. This mix of environmental signals and insults is highly variable and most certainly locale dependent. The potential for an organism to grow and divide within any locale or ecological niche is determined genetically by its repertoire of genes and by its capacity to induce new gene expression to cope with new environments. Often a bacterial infection results from an organism moving from an environment where its presence is benign (e.g., the gastrointestinal system) to another environment where it poses a serious problem (e.g., the urinary tract). This movement between ecological niches requires that the organism “sense” its presence in the new environment and “respond” by expressing new genetic information to permit it to occupy and grow within it. Success in this endeavor is the result of the sum of incremental genetic responses to the new environment of the host." @default.
- W2115285855 created "2016-06-24" @default.
- W2115285855 creator A5015672177 @default.
- W2115285855 creator A5067196656 @default.
- W2115285855 date "1998-07-01" @default.
- W2115285855 modified "2023-10-12" @default.
- W2115285855 title "Two-Component Signal Transduction as a Target for Microbial Anti-Infective Therapy" @default.
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- W2115285855 doi "https://doi.org/10.1128/aac.42.7.1529" @default.
- W2115285855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/105640" @default.
- W2115285855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9660978" @default.
- W2115285855 hasPublicationYear "1998" @default.
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