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- W2115292852 abstract "The angiotensin I-converting enzyme (ACE) converts the decapeptide angiotensin I (Ang I) into angiotensin II by releasing the C-terminal dipeptide. A novel approach combining enzymatic and electron paramagnetic resonance (EPR) studies was developed to determine the enzyme effect on Ang I containing the paramagnetic 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid (TOAC) at positions 1, 3, 8, and 9. Biological assays indicated that TOAC1-Ang I maintained partly the Ang I activity, and that only this derivative and the TOAC3-Ang I were cleaved by ACE. Quenching of Tyr4 fluorescence by TOAC decreased with increasing distance between both residues, suggesting an overall partially extended structure. However, the local bend known to be imposed by the substituted diglycine TOAC is probably responsible for steric hindrance, not allowing the analogues containing TOAC at positions 8 and 9 to act as substrates. In some cases, although substrates and products differ by only two residues, the difference between their EPR spectral lineshapes allows monitoring the enzymatic reaction as a function of time." @default.
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- W2115292852 date "2007-04-30" @default.
- W2115292852 modified "2023-10-16" @default.
- W2115292852 title "Analogues containing the paramagnetic amino acid TOAC as substrates for angiotensin I-converting enzyme" @default.
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- W2115292852 doi "https://doi.org/10.1016/j.febslet.2007.04.058" @default.
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