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- W2115294908 abstract "a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Histologically, this disease is characterized by endometrial gland and stroma with surrounding dense fibrous tissue. During the development of endometriotic lesions, excess fibrosis may lead to scarring and to altera- tion of the tissue function. It has been suggested that type I collagen is a major contributor to endometriosis-associated fibrosis. One approach to understanding the pathogenesis of endometriosis is to investigate the mechanisms underlying fibrogenesis associated with this disease. Using three-dimensional collagen gel culture model, we have evaluated the extracellular matrix contractility and myofibroblastic differentiation of endometriotic stromal cells. Endometriotic stromal cells showed enhanced extracellular matrix contractility in comparison with normal endometrial stromal cells. Activation of the Ras homology (Rho)/Rho- associated coiled-coil-forming protein kinase (ROCK)-mediated signaling pathway with simultaneously enhanced myofi- broblastic differentiation is involved in this mechanism. We have proposed the mevalonate-Rho/ROCK-mediated signal- ing pathways as possible therapeutic targets for the treatment of endometriosis-associated fibrosis. This paper is a review of the recent information concerning the mechanism of endometriosis-associated fibrosis, focusing on the contractility of endometriotic stromal cells. The modulators of mevalonate-Rho/ROCK signaling pathways were also evaluated as promising agents for the treatment and prevention of endometriosis-associated fibrosis." @default.
- W2115294908 created "2016-06-24" @default.
- W2115294908 creator A5010414975 @default.
- W2115294908 creator A5021106027 @default.
- W2115294908 creator A5038529411 @default.
- W2115294908 creator A5059587982 @default.
- W2115294908 date "2010-05-01" @default.
- W2115294908 modified "2023-10-16" @default.
- W2115294908 title "Mevalonate-Ras Homology (Rho)/Rho-Associated Coiled-Coil-Forming Protein Kinase (ROCK)-Mediated Signaling Pathway as a Therapeutic Target for the Treatment of Endometriosis-Associated Fibrosis" @default.
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