FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115344912> ?p ?o ?g. }

• W2115344912 endingPage "9895" @default.
• W2115344912 startingPage "9885" @default.
• W2115344912 abstract "The highly conserved coadapters CREB binding protein (CBP) and p300 form complexes with CREB as well as other DNA binding transcription factors to modulate chromatin remodeling and thus transcription. Human T-lymphotropic virus type 1 (HTLV-1) transcription is controlled, in part, by the CREB/ATF family of transcription factors which bind promoter sequences and function as complexes with the viral oncogenic protein Tax. We have reported that the nuclear localizing protein p30(II) of HTLV-1 functions as a transcription factor, differentially modulates CREB-responsive promoters, and is critical for maintenance of proviral loads in rabbits. In this study, we tested whether p30(II) directly interacts with CBP/p300 to modulate gene transcription. Gal4(BD)-p30(II)-mediated transactivation was enhanced following exogenous expression of p300 and was competitively repressed by the p300 binding protein, adenovirus E1A, and E1ACR2 (mutated for retinoblastoma binding but retaining p300 binding). In contrast, E1ACR1 (mutated for p300 binding) failed to alter Gal4(BD)-p30(II)-mediated transactivation. In addition, Gal4(BD)-p30(II)-mediated transactivation was competitively inhibited by the cotransfection of CMV-p30(II)-HA and CMV-Tax but could be rescued by exogenous p300. Importantly, we demonstrate that p30(II) colocalizes with p300 in cell nuclei and directly binds to CBP/p300 in cells. Deletion mutants of CBP/p300 were used to localize the site critical for binding p30(II) to a highly conserved KIX region. DNA binding assays confirmed the interference of p30(II) with the assembly of CREB-Tax-p300/CBP multiprotein complexes on 21-bp repeat oligonucleotides in vitro. Collectively, our results demonstrate that CBP/p300 is a cellular protein target for HTLV-1 p30(II) and mediates its transcriptional effects in vivo." @default.
• W2115344912 created "2016-06-24" @default.
• W2115344912 creator A5012947188 @default.
• W2115344912 creator A5016700147 @default.
• W2115344912 creator A5057019617 @default.
• W2115344912 creator A5067147780 @default.
• W2115344912 creator A5073657819 @default.
• W2115344912 creator A5078184468 @default.
• W2115344912 creator A5080259633 @default.
• W2115344912 date "2001-10-15" @default.
• W2115344912 modified "2023-10-17" @default.
• W2115344912 title "Human T-Lymphotropic Virus Type 1 p30 ^II Regulates Gene Transcription by Binding CREB Binding Protein/p300" @default.
• W2115344912 cites W108235626 @default.
• W2115344912 cites W1511815964 @default.
• W2115344912 cites W1525646048 @default.
• W2115344912 cites W1592701628 @default.
• W2115344912 cites W161079426 @default.
• W2115344912 cites W1879124647 @default.
• W2115344912 cites W1884928119 @default.
• W2115344912 cites W1964337986 @default.
• W2115344912 cites W1967404701 @default.
• W2115344912 cites W1977047500 @default.
• W2115344912 cites W1977186059 @default.
• W2115344912 cites W1981100890 @default.
• W2115344912 cites W1988149301 @default.
• W2115344912 cites W1994024013 @default.
• W2115344912 cites W1996814601 @default.
• W2115344912 cites W1999609085 @default.
• W2115344912 cites W2004520528 @default.
• W2115344912 cites W2004988279 @default.
• W2115344912 cites W2010605653 @default.
• W2115344912 cites W2015773923 @default.
• W2115344912 cites W2024128408 @default.
• W2115344912 cites W2027874507 @default.
• W2115344912 cites W2030571655 @default.
• W2115344912 cites W2033529039 @default.
• W2115344912 cites W2038552607 @default.
• W2115344912 cites W2040648539 @default.
• W2115344912 cites W2043331982 @default.
• W2115344912 cites W2049986428 @default.
• W2115344912 cites W2067551941 @default.
• W2115344912 cites W2072924157 @default.
• W2115344912 cites W2078190250 @default.
• W2115344912 cites W2079964631 @default.
• W2115344912 cites W2083080708 @default.
• W2115344912 cites W2085195718 @default.
• W2115344912 cites W2088534912 @default.
• W2115344912 cites W2090025028 @default.
• W2115344912 cites W2093293884 @default.
• W2115344912 cites W2094535486 @default.
• W2115344912 cites W2099566987 @default.
• W2115344912 cites W2108048093 @default.
• W2115344912 cites W2118433514 @default.
• W2115344912 cites W2126663486 @default.
• W2115344912 cites W2135668733 @default.
• W2115344912 cites W2138256964 @default.
• W2115344912 cites W2143241514 @default.
• W2115344912 cites W2144390370 @default.
• W2115344912 cites W2149138755 @default.
• W2115344912 cites W2152458930 @default.
• W2115344912 cites W2157694435 @default.
• W2115344912 cites W2179700842 @default.
• W2115344912 cites W2248056767 @default.
• W2115344912 cites W2315748521 @default.
• W2115344912 cites W2320166014 @default.
• W2115344912 cites W2325079156 @default.
• W2115344912 cites W2327806992 @default.
• W2115344912 cites W47716512 @default.
• W2115344912 doi "https://doi.org/10.1128/jvi.75.20.9885-9895.2001" @default.
• W2115344912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/114560" @default.
• W2115344912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11559821" @default.
• W2115344912 hasPublicationYear "2001" @default.
• W2115344912 type Work @default.
• W2115344912 sameAs 2115344912 @default.
• W2115344912 citedByCount "85" @default.
• W2115344912 countsByYear W21153449122012 @default.
• W2115344912 countsByYear W21153449122013 @default.
• W2115344912 countsByYear W21153449122014 @default.
• W2115344912 countsByYear W21153449122015 @default.
• W2115344912 countsByYear W21153449122016 @default.
• W2115344912 countsByYear W21153449122018 @default.
• W2115344912 countsByYear W21153449122019 @default.
• W2115344912 countsByYear W21153449122020 @default.
• W2115344912 countsByYear W21153449122022 @default.
• W2115344912 countsByYear W21153449122023 @default.
• W2115344912 crossrefType "journal-article" @default.
• W2115344912 hasAuthorship W2115344912A5012947188 @default.
• W2115344912 hasAuthorship W2115344912A5016700147 @default.
• W2115344912 hasAuthorship W2115344912A5057019617 @default.
• W2115344912 hasAuthorship W2115344912A5067147780 @default.
• W2115344912 hasAuthorship W2115344912A5073657819 @default.
• W2115344912 hasAuthorship W2115344912A5078184468 @default.
• W2115344912 hasAuthorship W2115344912A5080259633 @default.
• W2115344912 hasBestOaLocation W21153449121 @default.
• W2115344912 hasConcept C101762097 @default.
• W2115344912 hasConcept C104317684 @default.
• W2115344912 hasConcept C107824862 @default.
• W2115344912 hasConcept C1292079 @default.

• next