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- W2115369480 endingPage "473" @default.
- W2115369480 startingPage "455" @default.
- W2115369480 abstract "Mutations stimulate evolutionary change and lead to birth defects and cancer in humans as well as to antibiotic resistance in bacteria. According to the classic view, most mutations arise in dividing cells and result from uncorrected errors of S-phase DNA replication, which is highly accurate because of the involvement of selective DNA polymerases and efficient error-correcting mechanisms. In contrast, studies in bacteria and yeast reveal that DNA synthesis associated with repair of double-strand chromosomal breaks (DSBs) by homologous recombination is highly inaccurate, thus making DSBs and their repair an important source of mutations. Different error-prone mechanisms appear to operate in different repair scenarios. In the filling in of single-stranded DNA regions, error-prone translesion DNA polymerases appear to produce most errors. In contrast, in gene conversion gap repair and in break-induced replication, errors are independent of translesion polymerases, and many mutations have the signatures of template switching during DNA repair synthesis. DNA repair also appears to create complex copy-number variants. Overall, homologous recombination, which is traditionally considered a safe pathway of DSB repair, is an important source of mutagenesis that may contribute to human disease and evolution." @default.
- W2115369480 created "2016-06-24" @default.
- W2115369480 creator A5048113506 @default.
- W2115369480 creator A5070502223 @default.
- W2115369480 date "2012-12-15" @default.
- W2115369480 modified "2023-10-02" @default.
- W2115369480 title "Mutations Arising During Repair of Chromosome Breaks" @default.
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