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• W2115380923 abstract "The opportunistic pathogen Staphylococcus aureus encounters a wide variety of fluid shear levels within the human host, and they may play a key role in dictating whether this organism adopts a commensal interaction with the host or transitions to cause disease. By using rotating-wall vessel bioreactors to create a physiologically relevant, low-fluid-shear environment, S. aureus was evaluated for cellular responses that could impact its colonization and virulence. S. aureus cells grown in a low-fluid-shear environment initiated a novel attachment-independent biofilm phenotype and were completely encased in extracellular polymeric substances. Compared to controls, low-shear-cultured cells displayed slower growth and repressed virulence characteristics, including decreased carotenoid production, increased susceptibility to oxidative stress, and reduced survival in whole blood. Transcriptional whole-genome microarray profiling suggested alterations in metabolic pathways. Further genetic expression analysis revealed downregulation of the RNA chaperone Hfq, which parallels low-fluid-shear responses of certain Gram-negative organisms. This is the first study to report an Hfq association with fluid shear in a Gram-positive organism, suggesting an evolutionarily conserved response to fluid shear among structurally diverse prokaryotes. Collectively, our results suggest S. aureus responds to a low-fluid-shear environment by initiating a biofilm/colonization phenotype with diminished virulence characteristics, which could lead to insight into key factors influencing the divergence between infection and colonization during the initial host-pathogen interaction." @default.
• W2115380923 created "2016-06-24" @default.
• W2115380923 creator A5012748720 @default.
• W2115380923 creator A5066456098 @default.
• W2115380923 creator A5090243555 @default.
• W2115380923 creator A5091346776 @default.
• W2115380923 date "2011-09-15" @default.
• W2115380923 modified "2023-09-30" @default.
• W2115380923 title "Induction of Attachment-Independent Biofilm Formation and Repression of <i>hfq</i> Expression by Low-Fluid-Shear Culture of Staphylococcus aureus" @default.
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• W2115380923 doi "https://doi.org/10.1128/aem.00175-11" @default.
• W2115380923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3187170" @default.
• W2115380923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21803898" @default.
• W2115380923 hasPublicationYear "2011" @default.
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