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• W2115383745 endingPage "1919" @default.
• W2115383745 startingPage "1905" @default.
• W2115383745 abstract "Eukaryotic cells regulate the progression and integrity of DNA replication forks to maintain genomic stability and couple DNA synthesis to other processes. The budding yeast proteins Mrc1 and Tof1 associate with the putative MCM–Cdc45 helicase and limit progression of the replisome when nucleotides are depleted, and the checkpoint kinases Mec1 and Rad53 stabilize such stalled forks and prevent disassembly of the replisome. Forks also pause transiently during unperturbed chromosome replication, at sites where nonnucleosomal proteins bind DNA tightly. We describe a method for inducing prolonged pausing of forks at protein barriers assembled at unique sites on a yeast chromosome, allowing us to examine for the first time the effects of pausing upon replisome integrity. We show that paused forks maintain an intact replisome that contains Mrc1, Tof1, MCM–Cdc45, GINS, and DNA polymerases α and ϵ and that recruits the Rrm3 helicase. Surprisingly, pausing does not require Mrc1, although Tof1 and Csm3 are both important. In addition, the integrity of the paused forks does not require Mec1, Rad53, or recombination. We also show that paused forks at analogous barriers in the rDNA are regulated similarly. These data indicate that paused and stalled eukaryotic replisomes resemble each other but are regulated differently." @default.
• W2115383745 created "2016-06-24" @default.
• W2115383745 creator A5020161951 @default.
• W2115383745 creator A5058529935 @default.
• W2115383745 creator A5059339830 @default.
• W2115383745 creator A5073735040 @default.
• W2115383745 creator A5088998424 @default.
• W2115383745 date "2005-08-15" @default.
• W2115383745 modified "2023-10-14" @default.
• W2115383745 title "Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork" @default.
• W2115383745 cites W1481821763 @default.
• W2115383745 cites W1564916342 @default.
• W2115383745 cites W1604458367 @default.
• W2115383745 cites W1632341477 @default.
• W2115383745 cites W1669659061 @default.
• W2115383745 cites W1851841933 @default.
• W2115383745 cites W1887868672 @default.
• W2115383745 cites W1946215499 @default.
• W2115383745 cites W1964699435 @default.
• W2115383745 cites W1965423318 @default.
• W2115383745 cites W1968074226 @default.
• W2115383745 cites W1972973250 @default.
• W2115383745 cites W1975817822 @default.
• W2115383745 cites W1977839031 @default.
• W2115383745 cites W1978680674 @default.
• W2115383745 cites W1979015046 @default.
• W2115383745 cites W1979544330 @default.
• W2115383745 cites W1982166181 @default.
• W2115383745 cites W1990520992 @default.
• W2115383745 cites W1991539934 @default.
• W2115383745 cites W1992220084 @default.
• W2115383745 cites W1994183178 @default.
• W2115383745 cites W1996198025 @default.
• W2115383745 cites W1998415606 @default.
• W2115383745 cites W1999554125 @default.
• W2115383745 cites W1999624888 @default.
• W2115383745 cites W2003279154 @default.
• W2115383745 cites W2004536741 @default.
• W2115383745 cites W2008486131 @default.
• W2115383745 cites W2018399328 @default.
• W2115383745 cites W2021924340 @default.
• W2115383745 cites W2030350913 @default.
• W2115383745 cites W2034206561 @default.
• W2115383745 cites W2035542663 @default.
• W2115383745 cites W2037280667 @default.
• W2115383745 cites W2037491280 @default.
• W2115383745 cites W2040304693 @default.
• W2115383745 cites W2046066638 @default.
• W2115383745 cites W2050189514 @default.
• W2115383745 cites W2053259460 @default.
• W2115383745 cites W2055297703 @default.
• W2115383745 cites W2056590571 @default.
• W2115383745 cites W2057366479 @default.
• W2115383745 cites W2059185956 @default.
• W2115383745 cites W2069144966 @default.
• W2115383745 cites W2069607114 @default.
• W2115383745 cites W2074468648 @default.
• W2115383745 cites W2076101453 @default.
• W2115383745 cites W2076459721 @default.
• W2115383745 cites W2080862728 @default.
• W2115383745 cites W2081970237 @default.
• W2115383745 cites W2082507962 @default.
• W2115383745 cites W2093703127 @default.
• W2115383745 cites W2094569502 @default.
• W2115383745 cites W2097882687 @default.
• W2115383745 cites W2098324291 @default.
• W2115383745 cites W2101062348 @default.
• W2115383745 cites W2103646786 @default.
• W2115383745 cites W2110336860 @default.
• W2115383745 cites W2111493170 @default.
• W2115383745 cites W2113439921 @default.
• W2115383745 cites W2115239086 @default.
• W2115383745 cites W2116468279 @default.
• W2115383745 cites W2121258571 @default.
• W2115383745 cites W2126433544 @default.
• W2115383745 cites W2126918645 @default.
• W2115383745 cites W2130985414 @default.
• W2115383745 cites W2132181645 @default.
• W2115383745 cites W2134156532 @default.
• W2115383745 cites W2135227102 @default.
• W2115383745 cites W2137530487 @default.
• W2115383745 cites W2146830682 @default.
• W2115383745 cites W2147791743 @default.
• W2115383745 cites W2149947954 @default.
• W2115383745 cites W2151010172 @default.
• W2115383745 cites W2152231771 @default.
• W2115383745 cites W2155980033 @default.
• W2115383745 cites W2157479857 @default.
• W2115383745 cites W2158387328 @default.
• W2115383745 cites W2159680218 @default.
• W2115383745 cites W2169333620 @default.
• W2115383745 cites W2170609809 @default.
• W2115383745 cites W2172063118 @default.
• W2115383745 cites W2284205568 @default.
• W2115383745 doi "https://doi.org/10.1101/gad.337205" @default.
• W2115383745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1186190" @default.
• W2115383745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16103218" @default.
• W2115383745 hasPublicationYear "2005" @default.

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