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• W2115406537 endingPage "911" @default.
• W2115406537 startingPage "897" @default.
• W2115406537 abstract "Pheochromocytomas in von Hippel–Lindau (VHL) syndrome produce exclusively norepinephrine, whereas those in multiple endocrine neoplasia type 2 (MEN 2) produce epinephrine. This study examined the pathways activated in VHL-associated pheochromocytomas by comparing gene expression profiles in VHL and MEN 2 tumors in relationship to profiles in sporadic norepinephrine- and epinephrine-producing tumors. Larger and more distinct differences in gene expression among hereditary than sporadic tumors indicated the importance of the underlying mutation to gene expression profiles. Many of the genes over-expressed in VHL compared with MEN 2 tumors were clearly linked to the hypoxia-driven angiogenic pathways that are activated in VHL-associated tumorigenesis. Such genes included those for the glucose transporter, vascular endothelial growth factor (VEGF), placental growth factor, angiopoietin 2, tie-1, VEGF receptor 2 and its coreceptor, neuropilin-1. Other up-regulated genes, such as connective tissue growth factor, cysteine-rich 61, matrix metalloproteinase 1, vascular endothelial cadherin, tenascin C, stanniocalcin 1, and cyclooxygenases 1 and 2 are known to be involved in VEGF-regulated angiogenesis. Shared differences in expression of subsets of genes in norepinephrine- versus epinephrine-producing hereditary and sporadic pheochromocytomas indicated other differences in gene expression that may underlie the biochemical phenotype. Over-expression of the hypoxia-inducible transcription factor, HIF-2α, in norepinephrine-predominant sporadic and VHL tumors compared with epinephrine-producing tumors indicates that expression of this gene depends on the noradrenergic biochemical phenotype. The findings fit with the known expression of HIF-2α in norepinephrine-producing cells of the sympathetic nervous system and might explain both the development and noradrenergic biochemical phenotype of pheochromocytomas in VHL syndrome." @default.
• W2115406537 created "2016-06-24" @default.
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• W2115406537 date "2004-12-01" @default.
• W2115406537 modified "2023-10-18" @default.
• W2115406537 title "Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel–Lindau syndrome" @default.
• W2115406537 cites W1520229019 @default.
• W2115406537 cites W1554964268 @default.
• W2115406537 cites W1566538275 @default.
• W2115406537 cites W1581761562 @default.
• W2115406537 cites W1624342207 @default.
• W2115406537 cites W187530042 @default.
• W2115406537 cites W1893697461 @default.
• W2115406537 cites W1907985808 @default.
• W2115406537 cites W1968068296 @default.
• W2115406537 cites W1968434665 @default.
• W2115406537 cites W1971272556 @default.
• W2115406537 cites W1978173977 @default.
• W2115406537 cites W1989970148 @default.
• W2115406537 cites W1990844190 @default.
• W2115406537 cites W1992280608 @default.
• W2115406537 cites W1995280612 @default.
• W2115406537 cites W1995857537 @default.
• W2115406537 cites W1997661326 @default.
• W2115406537 cites W2008632796 @default.
• W2115406537 cites W2011540992 @default.
• W2115406537 cites W2016165171 @default.
• W2115406537 cites W2017759961 @default.
• W2115406537 cites W2019236201 @default.
• W2115406537 cites W2021802757 @default.
• W2115406537 cites W2024108040 @default.
• W2115406537 cites W2024514129 @default.
• W2115406537 cites W2027817200 @default.
• W2115406537 cites W2030790832 @default.
• W2115406537 cites W2034538165 @default.
• W2115406537 cites W2038467887 @default.
• W2115406537 cites W2042216712 @default.
• W2115406537 cites W2042702043 @default.
• W2115406537 cites W2043008229 @default.
• W2115406537 cites W2043508733 @default.
• W2115406537 cites W2048609180 @default.
• W2115406537 cites W2067234283 @default.
• W2115406537 cites W2070501893 @default.
• W2115406537 cites W2071178504 @default.
• W2115406537 cites W2086196048 @default.
• W2115406537 cites W2095900053 @default.
• W2115406537 cites W2099961094 @default.
• W2115406537 cites W2100555004 @default.
• W2115406537 cites W2103463360 @default.
• W2115406537 cites W2108034965 @default.
• W2115406537 cites W2109363337 @default.
• W2115406537 cites W2110065044 @default.
• W2115406537 cites W2113286636 @default.
• W2115406537 cites W2117779825 @default.
• W2115406537 cites W2120555366 @default.
• W2115406537 cites W2120657231 @default.
• W2115406537 cites W2121105636 @default.
• W2115406537 cites W2125495986 @default.
• W2115406537 cites W2127430336 @default.
• W2115406537 cites W2127937335 @default.
• W2115406537 cites W2135925543 @default.
• W2115406537 cites W2136875815 @default.
• W2115406537 cites W2137512583 @default.
• W2115406537 cites W2141046053 @default.
• W2115406537 cites W2141488374 @default.
• W2115406537 cites W2142599772 @default.
• W2115406537 cites W2145007812 @default.
• W2115406537 cites W2147035069 @default.
• W2115406537 cites W2149811187 @default.
• W2115406537 cites W2151209025 @default.
• W2115406537 cites W2152326461 @default.
• W2115406537 cites W2152890695 @default.
• W2115406537 cites W2159115343 @default.
• W2115406537 cites W2160363170 @default.
• W2115406537 cites W2163069245 @default.
• W2115406537 cites W2166859762 @default.
• W2115406537 cites W2170124424 @default.
• W2115406537 cites W2171244087 @default.
• W2115406537 cites W2171354819 @default.
• W2115406537 cites W238668910 @default.
• W2115406537 cites W43739530 @default.
• W2115406537 doi "https://doi.org/10.1677/erc.1.00838" @default.
• W2115406537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15613462" @default.
• W2115406537 hasPublicationYear "2004" @default.
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