FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115411982> ?p ?o ?g. }

• W2115411982 endingPage "497" @default.
• W2115411982 startingPage "485" @default.
• W2115411982 abstract "Haemorrhage induced by snake venom metalloproteinases (SVMPs) is a complex phenomenon resulting in capillary disruption and extravasation. This study analysed structural elements important for the interaction of four Bothrops jararaca SVMPs of different domain organisation and glycosylation levels with plasma and extracellular matrix proteins: HF3 (P-III class) is highly glycosylated and ~80 times more haemorrhagic than bothropasin (P-III class), which has a minor carbohydrate moiety; BJ-PI (P-I class) is not haemorrhagic and the DC protein is composed of disintegrin-like/cysteine-rich domains of bothropasin. HF3, bothropasin and BJ-PI showed different degradation profiles of fibrinogen, fibronectin, vitronectin, von Willebrand factor, collagens IV and VI, laminin and Matrigel; however, only bothropasin degraded collagen I. In solid-phase binding assays HF3 and bothropasin interacted with fibrinogen, fibronectin, laminin, collagens I and VI; the DC protein bound only to collagens I and VI; however, no binding of BJ-PI to these proteins was detected. N-deglycosylation caused loss of structural stability of bothropasin and BJ-PI but HF3 remained intact, although its haemorrhagic and fibrinogenolytic activities were partially impaired. Nevertheless, N-deglycosylated HF3 bound with higher affinity to collagens I and VI, although its proteolytic activity upon these collagens was not enhanced. This study demonstrates that features of carbohydrate moieties of haemorrhagic SVMPs may play a role in their interaction with substrates of the extracellular matrix, and the ability of SVMPs to degrade proteins in vitro does not correlate to their ability to cause haemorrhage, suggesting that novel, systemic approaches are necessary for understanding the mechanism of haemorrhage generation by SVMPs." @default.
• W2115411982 created "2016-06-24" @default.
• W2115411982 creator A5003157951 @default.
• W2115411982 creator A5010809600 @default.
• W2115411982 creator A5029271049 @default.
• W2115411982 creator A5041069370 @default.
• W2115411982 creator A5059560972 @default.
• W2115411982 creator A5091741771 @default.
• W2115411982 date "2010-01-01" @default.
• W2115411982 modified "2023-10-10" @default.
• W2115411982 title "New insights into the structural elements involved in the skin haemorrhage induced by snake venom metalloproteinases" @default.
• W2115411982 cites W1538333669 @default.
• W2115411982 cites W1545427707 @default.
• W2115411982 cites W1565563859 @default.
• W2115411982 cites W1591272093 @default.
• W2115411982 cites W1888609755 @default.
• W2115411982 cites W1939750459 @default.
• W2115411982 cites W1965520907 @default.
• W2115411982 cites W1967674281 @default.
• W2115411982 cites W1969765250 @default.
• W2115411982 cites W1974104033 @default.
• W2115411982 cites W1979816412 @default.
• W2115411982 cites W1981148940 @default.
• W2115411982 cites W1984267713 @default.
• W2115411982 cites W1985219531 @default.
• W2115411982 cites W1991363427 @default.
• W2115411982 cites W1992346641 @default.
• W2115411982 cites W1993988581 @default.
• W2115411982 cites W1994965374 @default.
• W2115411982 cites W1995516187 @default.
• W2115411982 cites W1997419150 @default.
• W2115411982 cites W2000383671 @default.
• W2115411982 cites W2003977686 @default.
• W2115411982 cites W2007635285 @default.
• W2115411982 cites W2008511690 @default.
• W2115411982 cites W2009552835 @default.
• W2115411982 cites W2018327701 @default.
• W2115411982 cites W2030246164 @default.
• W2115411982 cites W2034956882 @default.
• W2115411982 cites W2035605729 @default.
• W2115411982 cites W2039278322 @default.
• W2115411982 cites W2044516757 @default.
• W2115411982 cites W2050964385 @default.
• W2115411982 cites W2053041551 @default.
• W2115411982 cites W2055785948 @default.
• W2115411982 cites W2077043569 @default.
• W2115411982 cites W2082228931 @default.
• W2115411982 cites W2082339460 @default.
• W2115411982 cites W2090117493 @default.
• W2115411982 cites W2092729970 @default.
• W2115411982 cites W2094001578 @default.
• W2115411982 cites W2097966029 @default.
• W2115411982 cites W2100837269 @default.
• W2115411982 cites W2106028065 @default.
• W2115411982 cites W2111817213 @default.
• W2115411982 cites W2145837099 @default.
• W2115411982 cites W2146194904 @default.
• W2115411982 cites W2164434522 @default.
• W2115411982 cites W2345436650 @default.
• W2115411982 cites W23530191 @default.
• W2115411982 cites W2411363425 @default.
• W2115411982 cites W2471318429 @default.
• W2115411982 cites W1989192235 @default.
• W2115411982 doi "https://doi.org/10.1160/th09-12-0855" @default.
• W2115411982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20664911" @default.
• W2115411982 hasPublicationYear "2010" @default.
• W2115411982 type Work @default.
• W2115411982 sameAs 2115411982 @default.
• W2115411982 citedByCount "52" @default.
• W2115411982 countsByYear W21154119822012 @default.
• W2115411982 countsByYear W21154119822013 @default.
• W2115411982 countsByYear W21154119822014 @default.
• W2115411982 countsByYear W21154119822015 @default.
• W2115411982 countsByYear W21154119822016 @default.
• W2115411982 countsByYear W21154119822017 @default.
• W2115411982 countsByYear W21154119822018 @default.
• W2115411982 countsByYear W21154119822019 @default.
• W2115411982 countsByYear W21154119822020 @default.
• W2115411982 countsByYear W21154119822021 @default.
• W2115411982 countsByYear W21154119822022 @default.
• W2115411982 countsByYear W21154119822023 @default.
• W2115411982 crossrefType "journal-article" @default.
• W2115411982 hasAuthorship W2115411982A5003157951 @default.
• W2115411982 hasAuthorship W2115411982A5010809600 @default.
• W2115411982 hasAuthorship W2115411982A5029271049 @default.
• W2115411982 hasAuthorship W2115411982A5041069370 @default.
• W2115411982 hasAuthorship W2115411982A5059560972 @default.
• W2115411982 hasAuthorship W2115411982A5091741771 @default.
• W2115411982 hasConcept C108625454 @default.
• W2115411982 hasConcept C109523444 @default.
• W2115411982 hasConcept C164144092 @default.
• W2115411982 hasConcept C167814343 @default.
• W2115411982 hasConcept C181199279 @default.
• W2115411982 hasConcept C185592680 @default.
• W2115411982 hasConcept C189165786 @default.
• W2115411982 hasConcept C203014093 @default.
• W2115411982 hasConcept C2776725428 @default.
• W2115411982 hasConcept C2778259572 @default.

• next