FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115425140> ?p ?o ?g. }

• W2115425140 abstract "Constitutive activating mutations of G protein-coupled receptors, such as that of TSH, have been implicated in the tumorigenesis of human endocrine neoplasms, such as thyroid adenomas. In a previous study we reported that constitutive activating point mutations of the ACTH receptor (ACTH-R) gene, a member of the G protein-coupled receptor superfamily, were not present in hormone-secreting and nonsecretory adrenocortical neoplasms. In this study, we investigated whether allelic loss of the ACTH-R gene is present in sporadic adrenal tumors. We identified a PstI polymorphism in the promoter region 3 kilobases upstream of the coding region of the ACTH-R gene. The rate of heterozygosity for this polymorphism in 99 unrelated Caucasian individuals was 53.5%. Using this polymorphism, we analyzed loss of heterozygosity (LOH) of the ACTH-R gene in 20 informative cases with benign and malignant adrenocortical tumors. Of 16 patients with benign lesions, LOH was present in 1 oncocytic nonfunctional adenoma, but not in 15 hyperfunctioning adenomas. Of 4 informative patients with adrenocortical carcinomas, LOH was present in 2 cases. Both patients had advanced tumor stages and showed a more rapid course than carcinoma patients without LOH. Analysis of the flanking region of the ACTH-R using the polymorphic microsatelite marker D18S37 and D18S40 showed that this deletion was confined to the ACTH-R gene. Northern blot experiments demonstrated reduced expression of ACTH-R messenger ribonucleic acid in the tumors with LOH of the ACTH-R gene, suggesting functional significance of this finding at the transcriptional level. We conclude that LOH of the ACTH-R gene is possibly involved in adrenal tumorigenesis, contributing to cellular dedifferentiation in adenomas and carcinomas." @default.
• W2115425140 created "2016-06-24" @default.
• W2115425140 creator A5005883410 @default.
• W2115425140 creator A5014771501 @default.
• W2115425140 creator A5017793957 @default.
• W2115425140 creator A5046164327 @default.
• W2115425140 creator A5076459020 @default.
• W2115425140 creator A5090695853 @default.
• W2115425140 date "1997-09-01" @default.
• W2115425140 modified "2023-09-23" @default.
• W2115425140 title "Deletion of the Adrenocorticotropin Receptor Gene in Human Adrenocortical Tumors: Implications for Tumorigenesis1" @default.
• W2115425140 cites W1567779734 @default.
• W2115425140 cites W1964074039 @default.
• W2115425140 cites W1965732784 @default.
• W2115425140 cites W1979420492 @default.
• W2115425140 cites W1990401009 @default.
• W2115425140 cites W2012968668 @default.
• W2115425140 cites W2014387626 @default.
• W2115425140 cites W2024431221 @default.
• W2115425140 cites W2029916687 @default.
• W2115425140 cites W2036740014 @default.
• W2115425140 cites W2039836243 @default.
• W2115425140 cites W2050281571 @default.
• W2115425140 cites W2051743705 @default.
• W2115425140 cites W2055541901 @default.
• W2115425140 cites W2060842751 @default.
• W2115425140 cites W2067981937 @default.
• W2115425140 cites W2072253048 @default.
• W2115425140 cites W2093094352 @default.
• W2115425140 cites W2112650529 @default.
• W2115425140 cites W2118109089 @default.
• W2115425140 cites W2315321516 @default.
• W2115425140 cites W26529857 @default.
• W2115425140 cites W2764475911 @default.
• W2115425140 cites W2999510508 @default.
• W2115425140 doi "https://doi.org/10.1210/jcem.82.9.4211" @default.
• W2115425140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9284742" @default.
• W2115425140 hasPublicationYear "1997" @default.
• W2115425140 type Work @default.
• W2115425140 sameAs 2115425140 @default.
• W2115425140 citedByCount "38" @default.
• W2115425140 countsByYear W21154251402012 @default.
• W2115425140 countsByYear W21154251402014 @default.
• W2115425140 countsByYear W21154251402015 @default.
• W2115425140 countsByYear W21154251402016 @default.
• W2115425140 crossrefType "journal-article" @default.
• W2115425140 hasAuthorship W2115425140A5005883410 @default.
• W2115425140 hasAuthorship W2115425140A5014771501 @default.
• W2115425140 hasAuthorship W2115425140A5017793957 @default.
• W2115425140 hasAuthorship W2115425140A5046164327 @default.
• W2115425140 hasAuthorship W2115425140A5076459020 @default.
• W2115425140 hasAuthorship W2115425140A5090695853 @default.
• W2115425140 hasBestOaLocation W21154251401 @default.
• W2115425140 hasConcept C104317684 @default.
• W2115425140 hasConcept C126322002 @default.
• W2115425140 hasConcept C134018914 @default.
• W2115425140 hasConcept C143589142 @default.
• W2115425140 hasConcept C177865409 @default.
• W2115425140 hasConcept C180754005 @default.
• W2115425140 hasConcept C2777428134 @default.
• W2115425140 hasConcept C2780103800 @default.
• W2115425140 hasConcept C2780546910 @default.
• W2115425140 hasConcept C2781399356 @default.
• W2115425140 hasConcept C502942594 @default.
• W2115425140 hasConcept C54355233 @default.
• W2115425140 hasConcept C555283112 @default.
• W2115425140 hasConcept C71315377 @default.
• W2115425140 hasConcept C71924100 @default.
• W2115425140 hasConcept C86803240 @default.
• W2115425140 hasConceptScore W2115425140C104317684 @default.
• W2115425140 hasConceptScore W2115425140C126322002 @default.
• W2115425140 hasConceptScore W2115425140C134018914 @default.
• W2115425140 hasConceptScore W2115425140C143589142 @default.
• W2115425140 hasConceptScore W2115425140C177865409 @default.
• W2115425140 hasConceptScore W2115425140C180754005 @default.
• W2115425140 hasConceptScore W2115425140C2777428134 @default.
• W2115425140 hasConceptScore W2115425140C2780103800 @default.
• W2115425140 hasConceptScore W2115425140C2780546910 @default.
• W2115425140 hasConceptScore W2115425140C2781399356 @default.
• W2115425140 hasConceptScore W2115425140C502942594 @default.
• W2115425140 hasConceptScore W2115425140C54355233 @default.
• W2115425140 hasConceptScore W2115425140C555283112 @default.
• W2115425140 hasConceptScore W2115425140C71315377 @default.
• W2115425140 hasConceptScore W2115425140C71924100 @default.
• W2115425140 hasConceptScore W2115425140C86803240 @default.
• W2115425140 hasLocation W21154251401 @default.
• W2115425140 hasLocation W21154251402 @default.
• W2115425140 hasOpenAccess W2115425140 @default.
• W2115425140 hasPrimaryLocation W21154251401 @default.
• W2115425140 hasRelatedWork W2001214726 @default.
• W2115425140 hasRelatedWork W2047253938 @default.
• W2115425140 hasRelatedWork W2050772215 @default.
• W2115425140 hasRelatedWork W2070619520 @default.
• W2115425140 hasRelatedWork W2074268135 @default.
• W2115425140 hasRelatedWork W2077667918 @default.
• W2115425140 hasRelatedWork W2108405883 @default.
• W2115425140 hasRelatedWork W2164206102 @default.
• W2115425140 hasRelatedWork W2313972896 @default.
• W2115425140 hasRelatedWork W2148508279 @default.
• W2115425140 isParatext "false" @default.

• next